A prospective observational study on safety and efficacy of metformin and its combination used in type-ii diabetes mellitus patients

Abstract

Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. This study was carried out with an objective to determine the efficacy of Metformin with other oral hypoglycemic agents, to educate the patients about the disease and use of drugs in diabetes mellitus and to evaluate which class of drugs in oral hypoglycemic agents with Metformin shows more effectiveness. The patients in each group received the medication for 8 weeks duration. A study was carried out about the comparative, efficacy of glimepiride and metformin in type-2 DM which was a meta-analysis of randomized controlled trials. The results of the study were that metformin alone does not show the efficacy than with Metformin+ Teneligliptin and Metformin + Glimepiride in overall efficacy of controlling FBS and PPBS. Combination of Metformin+ Glimepiride is more effective than Metformin+ Teneligliptin and Metformin alone. The findings from the study observed the combination of metformin efficacy to some extent.