Diagnosis of acute myocardial infarction before surgery: high-sensitivity troponin T or amino-terminal fragment of pro-brain natriuretic peptide type B?

Abstract

Currently, there are data in the literature about the importance of the aminoterminal fragment of pro-brain natriuretic peptide type B in the diagnosis of patients with acute myocardial infarction.The aim. To study preoperative levels of aminoterminal fragment of pro-brain natriuretic peptide type B and high-sensitivity troponin T in patients with acute myocardial infarction and to assess the significance of aminoterminal fragment of pro-brain natriuretic peptide type B in patients with this pathology.Materials and methods. We retrospectively analyzed 50 medical records of patients diagnosed with acute myocardial infarction.The results. Study of preoperative levels of aminoterminal fragment of pro-brain natriuretic peptide type B in patients with acute myocardial infarction showed that the values of aminoterminal fragment of pro-brain natriuretic peptide type B at hospital admission ranged from 127 to 600 pg/ml; correlated with left ventricular ejection fraction (r =-0,42, p < 0,05), severity of acute heart failure (r =+0,57, p < 0,05), and outcome of acute myocardial infarction (r =+0,45, p < 0,05). Assessment of the value of aminoterminal fragment of pro-brain natriuretic peptide type B in patients with acute myocardial infarction on the basis of comparison with high-sensitivity troponin T revealed no advantages of its use in this pathology as a marker of acute cardiomyocyte damage: aminoterminal fragment of pro-brain natriuretic peptide type B has less diagnostic and prognostic value than high-sensitivity troponin T. Diagnosis of acute myocardial infarction before surgery: highly sensitive troponin T or aminoterminal fragment of pro-brain natriuretic peptide type B?