Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin

Abstract

An easy and economical spectrophotometric method has been developed for the determination of atorvastatin from tablet formulation. This method is based on the formation of a blue-colored charge transfer complex of Atorvastatin with quinalizarin in methanol medium. The blue colored complex gives maximum absorbance at 573 nm. In order to develop the quantitative analysis method of atorvastatin, several parameters such as the type of solvent, the effect of reagent concentration, and the reaction time and temperature on absorbance of complex were investigated. It was determined that the optimum Quinz solution (0.5x10-³ M) was 3mL and the optimum temperature of the reaction was room temperature. Beer’s law range of proposed method is found 10-100 µg.mL-1. LOD and LOQ of the proposed method were found as 1.49 µg.mL-1 and 4.98 µg.mL-1, respectively. As a result, this proposed method can be used in the quantitative analysis of atorvastatin in tablet formulations