Pathophysiological aspects of microgravity and gravity therapy in cardiovascular diseases

A. V. Pereshein, S. Kuznetsova, D. A. Petrova, T. Potemina
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Abstract

Deconditioning in space from gravity deprivation, the problems of the consequences of modern sedentary lifestyle, bed rest and changes observed in sedentary aging demonstrate similar mechanisms of development, which are interpreted as disorders of mechanotransduction. Tensegrity theory provides the framework for understanding how external and internal mechanical forces influence biological control at the molecular and cellular levels in conditions associated with a sharp and steady disappearance of the gravitational vector signal. Microgravity causes pathologies such as severe loss of bone density and skeletal muscle strength, loss of functional capacity of the cardiovascular system, immune system and other disorders. The effect on the human body for therapeutic and preventive purposes with various parameters of artificial gravity is a modern and highly effective technology of restorative medicine.   The aim of this lecture is to summarize the most important findings about the effects of gravitational therapy in different, mainly vascular based pathologies according to literary sources.
微重力和重力疗法对心血管疾病的病理生理学影响
重力剥夺导致的空间失调、现代久坐生活方式的后果问题、卧床休息以及在久坐老化过程中观察到的变化,都显示出类似的发展机制,被解释为机械传导失调。张力理论为理解外部和内部机械力如何在重力矢量信号急剧稳定消失的条件下影响分子和细胞水平的生物控制提供了框架。微重力会导致病理现象,如骨密度和骨骼肌强度严重下降、心血管系统功能丧失、免疫系统和其他疾病。利用人工重力的各种参数对人体产生治疗和预防作用,是一种高效的现代修复医学技术。 本讲座的目的是根据文献资料,总结重力疗法对不同病症(主要是血管性病症)影响的最重要发现。
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