Primary retroperitoneal choriocarcinoma with lung and liver metastasis in a male patient: case report

IF 1.4 4区 医学 Q4 ONCOLOGY
Guimei Wang, Ronghui Li
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Abstract

Abstract Objectives Non-gestational primary choriocarcinoma is an extremely rare malignant tumor with atypical clinical symptoms, especially in males. It usually occurs in the midline of the body, such as the mediastinum and retroperitoneum. Pathological diagnosis of primary retroperitoneal choriocarcinoma presents many challenges. More importantly, it is insensitive to therapy and has a poor prognosis. To date, there is still no standard treatment strategy for primary choriocarcinoma. Case presentation This case report presented a 27-year-old male with acute abdominal pain as the main symptom. And then, retroperitoneal choriocarcinoma with lung and liver metastasis was diagnosed. Palliative surgery was performed to alleviate the abdominal pain but complete tumor removal was not achieved. Subsequently, we gave the treatment with cytotoxic chemotherapy and immune checkpoint inhibitor blockade. The tumor was significantly reduced in size after six cycles of immunotherapy and chemotherapy, and also β-hCG level returned to normal. The tumor was not in complete remission, so penpulimab immuno-maintenance therapy was given. So far, the tumor control is stable, and the patient’s quality of life is also very well. Conclusions Pathological diagnosis of primary choriocarcinoma is very necessary, and the related molecular markers can assist. Immunotherapy combined with chemotherapy is effective in the treatment of primary retroperitoneal choriocarcinoma.
一名男性患者的原发性腹膜后绒毛膜癌伴肺和肝转移:病例报告
摘要 目的 非妊娠原发性绒毛膜癌是一种极为罕见的恶性肿瘤,临床症状不典型,尤其多见于男性。它通常发生在身体中线,如纵隔和腹膜后。原发性腹膜后绒毛膜癌的病理诊断面临许多挑战。更重要的是,它对治疗不敏感,预后较差。迄今为止,原发性绒毛膜癌仍没有标准的治疗策略。病例介绍 本病例报告的患者为一名 27 岁男性,主要症状为急性腹痛。随后确诊为腹膜后绒毛膜癌,并伴有肺和肝转移。我们进行了姑息手术以缓解腹痛,但未能完全切除肿瘤。随后,我们给予了细胞毒化疗和免疫检查点抑制剂阻断治疗。经过六个周期的免疫治疗和化疗,肿瘤明显缩小,β-hCG水平也恢复正常。由于肿瘤没有完全缓解,因此患者接受了 Penpulimab 免疫维持治疗。目前,肿瘤控制稳定,患者的生活质量也很好。结论 原发性绒毛膜癌的病理诊断非常必要,相关的分子标记物可以辅助诊断。免疫治疗联合化疗对原发性腹膜后绒毛膜癌的治疗是有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oncologie
Oncologie 医学-肿瘤学
CiteScore
1.30
自引率
11.10%
发文量
32
审稿时长
6-12 weeks
期刊介绍: Oncologie is aimed to the publication of high quality original research articles, review papers, case report, etc. with an active interest in vivo or vitro study of cancer biology. Study relating to the pathology, diagnosis, and advanced treatment of all types of cancers, as well as research from any of the disciplines related to this field of interest. The journal has English and French bilingual publication.
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