Hallmarks of stemness in mammalian tissues.

Joep Beumer, Hans Clevers
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Abstract

All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to replace lost tissue through division. We discuss a set of six complementary hallmarks that are key enabling features of this basic function. These include longevity and self-renewal, multipotency, transplantability, plasticity, dependence on niche signals, and maintenance of genome integrity. We discuss these hallmarks in the context of some of the best-understood adult stem cell niches.

哺乳动物组织干性的特征
所有成人组织都会经历磨损。大多数组织可以通过常驻干细胞的活动来补偿细胞损失。虽然不同成人(解读:出生后)组织的细胞维持策略大相径庭,但干细胞的功能最好地定义为其通过分裂来替代流失组织的能力。我们讨论了这一基本功能的六大互补特征。这些特征包括长寿和自我更新、多能性、可移植性、可塑性、对生态位信号的依赖性以及保持基因组完整性。我们将结合一些最易理解的成体干细胞龛位来讨论这些特征。
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