High-Performance Liquid Chromatography Methods for Determining the Purity of Drugs with Weak UV Chromophores - A Review.

IF 4.2 2区化学 Q1 CHEMISTRY, ANALYTICAL

Critical reviews in analytical chemistry Pub Date : 2024-01-05 DOI:10.1080/10408347.2023.2291815

Elżbieta Sobolewska, Magdalena Biesaga

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引用次数: 0

Abstract

High-performance liquid chromatography (HPLC) is one of the most useful techniques for the separation and determination of new drugs with a complex nature. The selection of an HPLC detector depends on the chemical nature of molecules, potential impurities, matrix of the sample, sensitivity, availability, and/or cost of the detector. HPLC methods with UV/Vis detectors are the most used and simple analytical procedures in pharmaceutical applications, but it is limited to compounds that possess a chromophore. Hence, this review provides an overview on the development of analytical methods for compounds with weak chromophores. The review described selected papers about HPLC based methods in the PubMed, Scopus, Semantic Scholar and ScienceDirect databases, basically between 2006 and 2023. Of the analytical studies, the HPLC methods with UV-Vis, FLD, CAD, ELSD, RID, ECD, CLND and MS detection were found. This study is a comparison of different types of detection that are described in scientific literature and are routinely used for compounds with weak chromophores. It is expected that this review will be helpful for scientists in the analytical development fields to improve research related to the drug candidates and to ensure its quality according to regulatory levels.

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测定具有弱紫外发色团的药物纯度的高效液相色谱法 - 综述。

高效液相色谱法（HPLC）是分离和测定性质复杂的新药最有用的技术之一。高效液相色谱检测器的选择取决于分子的化学性质、潜在杂质、样品基质、检测器的灵敏度、可用性和/或成本。使用紫外/可见检测器的高效液相色谱法是制药应用中最常用、最简单的分析程序，但仅限于具有发色团的化合物。因此，本综述概述了弱发色团化合物分析方法的发展情况。综述选取了 PubMed、Scopus、Semantic Scholar 和 ScienceDirect 数据库中有关基于高效液相色谱法的论文，时间基本在 2006 年至 2023 年之间。在这些分析研究中，发现了采用 UV-Vis、FLD、CAD、ELSD、RID、ECD、CLND 和 MS 检测的 HPLC 方法。本研究对科学文献中描述的不同检测类型进行了比较，这些检测类型通常用于具有弱发色团的化合物。预计本综述将有助于分析开发领域的科学家改进与候选药物相关的研究，并确保其质量符合法规要求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in analytical chemistry 化学-分析化学

CiteScore

12.00

自引率

4.00%

发文量

137

审稿时长

6 months

期刊介绍： Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.