Risk factors of first thrombosis in obstetric antiphospholipid syndrome

IF 3.7 2区医学 Q1 RHEUMATOLOGY

Lupus Science & Medicine Pub Date : 2024-01-01 DOI:10.1136/lupus-2023-001044

Liang Luo, Qingmeng Cai, Xiangjun Liu, Yuke Hou, Chun Li

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引用次数: 0

Abstract

Objective There is limited evidence on long-term thrombosis risk in patients with obstetric antiphospholipid syndrome (OAPS). This study aimed to investigate the clinical features and risk factors associated with the first thrombosis in patients with isolated OAPS. Methods Data from patients with isolated OAPS were collected. All patients were followed up until the first thrombotic event during or after delivery or until the end of the study. Logistic regression analysis identified independent risk factors associated with the first thrombosis in patients with isolated OAPS. Results The study enrolled 186 patients with OAPS. During a mean 5.4-year follow-up, 11 (5.9%) patients experienced thrombotic events. Multivariate binary logistic regression analysis revealed that triple-positive antiphospholipid antibodies (aPLs, OR=11.662, 95% CI=2.117 to 64.243, p=0.005) and hypocomplementemia (OR=9.047, 95% CI=1.530 to 53.495, p=0.015) were identified as independent risk factors for the first thrombosis in OAPS, after adjustment for low-dose aspirin and hydroxychloroquine. Conclusions Triple-positive aPLs and hypocomplementemia are risk factors for the first thrombosis in patients with OAPS. Data are available upon reasonable request.

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产科抗磷脂综合征首次血栓形成的风险因素

目的关于产科抗磷脂综合征（OAPS）患者长期血栓形成风险的证据有限。本研究旨在调查与孤立性 OAPS 患者首次血栓形成相关的临床特征和风险因素。方法收集孤立性 OAPS 患者的数据。对所有患者进行随访，直至其在分娩过程中或分娩后发生首次血栓形成或研究结束。逻辑回归分析确定了与孤立性 OAPS 患者首次血栓形成相关的独立风险因素。结果该研究共纳入 186 名 OAPS 患者。在平均 5.4 年的随访期间，11 例（5.9%）患者发生了血栓事件。多变量二元逻辑回归分析显示，在对小剂量阿司匹林和羟氯喹进行调整后，抗磷脂抗体三重阳性（aPLs，OR=11.662，95% CI=2.117~64.243，p=0.005）和低补体血症（OR=9.047，95% CI=1.530~53.495，p=0.015）被确定为 OAPS 首次血栓形成的独立危险因素。结论 aPL 三阳性和低补体血症是 OAPS 患者首次血栓形成的风险因素。如有合理要求，可提供相关数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lupus Science & Medicine RHEUMATOLOGY-

CiteScore

5.30

自引率

7.70%

发文量

审稿时长

15 weeks

期刊介绍： Lupus Science & Medicine is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. It is the first lupus-specific open access journal in the world and was developed in response to the need for a barrier-free forum for publication of groundbreaking studies in lupus. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology, nephrology, immunology, pediatrics, cardiology, hepatology, pulmonology, obstetrics and gynecology, and psychiatry.