ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia
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ROS 诱导的一碳代谢重编程和 S-腺苷蛋氨酸介导的表观遗传修饰在 IL-10 产生的 B 细胞中的应用有助于肺炎的缓解
B 细胞具有重要的免疫调节功能,它通过分泌 IL-10 和 TGFβ,并与活化的 CD4+ T 细胞相互作用。B 细胞这种不依赖抗体的功能有助于改善自身免疫性疾病或感染引起的组织损伤。在本期《细胞与分子免疫学》(Cellular and Molecular Immunology)杂志中,Fu 等人证实调节性 B(Breg)细胞在解决铜绿假单胞菌诱发的肺炎中发挥着关键作用[1]。作者通过研究肺炎进展和缓解过程中支气管肺泡灌洗液中的免疫细胞,发现 B 细胞是维持组织稳态的关键调节因子。B 细胞水平在感染四天后显著增加,与疾病严重程度成反比,免疫调节需要 IL-10 的表达。
期刊介绍:
Cellular & Molecular Immunology, a monthly journal from the Chinese Society of Immunology and the University of Science and Technology of China, serves as a comprehensive platform covering both basic immunology research and clinical applications. The journal publishes a variety of article types, including Articles, Review Articles, Mini Reviews, and Short Communications, focusing on diverse aspects of cellular and molecular immunology.