Knowledge and approach towards Helicobacter pylori diagnosis and management among primary care physicians in Cameroon: a cross-sectional study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-01 DOI:10.1093/trstmh/trad089

Nkengeh Tazinkeng, Joao Filipe Monteiro, Bill-Erich Mbianyor, Avis Anya Nowbuth, Monela Ntonifor, Claudia Evenge, Alick Nkhoma, Steven F Moss, Akwi W Asombang

{"title":"Knowledge and approach towards Helicobacter pylori diagnosis and management among primary care physicians in Cameroon: a cross-sectional study.","authors":"Nkengeh Tazinkeng, Joao Filipe Monteiro, Bill-Erich Mbianyor, Avis Anya Nowbuth, Monela Ntonifor, Claudia Evenge, Alick Nkhoma, Steven F Moss, Akwi W Asombang","doi":"10.1093/trstmh/trad089","DOIUrl":null,"url":null,"abstract":"Background: Low- and middle-income countries have a high prevalence of Helicobacter pylori infection (HPI). In Cameroon, the majority of HPIs are diagnosed and treated by primary care physicians (PCPs). We sought to assess the knowledge and practices of PCPs in the diagnosis and management of HPI in Cameroon.Methods: A hospital-based cross-sectional study was carried out in four randomly selected regions of Cameroon from November 2021 to June 2022. In each of the selected regions, PCPs were recruited by non-probability convenience sampling and interviewed using a pre-structured questionnaire. Chi-squared, Fisher's exact and Student's t-tests were performed for descriptive analyses. Multivariable logistic regression was used to examine associations between knowledge and practice, with the model adjusted by age of the PCP, geographic region, number of patients and years in practice. Analysis was performed in SAS version 9.4 (SAS Institute, Cary, NC, USA).Results: A total of 382 PCPs were included in the analysis. The majority (60.0%) were males between the ages of 20-29 y (64.1%). Most PCPs (80.9%) reported that HPI is the cause of gastroesophageal reflux disease and 41.8% reported that HPI is the main cause of dyspeptic symptoms. The dominant diagnostic tests used for HPI were serology (52.8%) and stool antigen (30.9%). The most frequently used first-line therapies were amoxicillin (AMX), clarithromycin (CLA), metronidazole (MNZ) and proton pump inhibitor (PPI) concomitant therapy (32.2%), AMX-CLA-PPI triple therapy (18.6%) and AMX-MNZ-PPI triple therapy (13.1%). Half of the practitioners (48.6%) treat HPI empirically, without positive H. pylori testing. About half of the PCPs (48%) do not request laboratory confirmation of H. pylori eradication following treatment.Conclusions: There is inadequate knowledge and significant differences in the clinical approach towards HPI among PCPs in Cameroon. We recommend more teaching programs and continuous medical education on HPI.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/trstmh/trad089","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Low- and middle-income countries have a high prevalence of Helicobacter pylori infection (HPI). In Cameroon, the majority of HPIs are diagnosed and treated by primary care physicians (PCPs). We sought to assess the knowledge and practices of PCPs in the diagnosis and management of HPI in Cameroon.

Methods: A hospital-based cross-sectional study was carried out in four randomly selected regions of Cameroon from November 2021 to June 2022. In each of the selected regions, PCPs were recruited by non-probability convenience sampling and interviewed using a pre-structured questionnaire. Chi-squared, Fisher's exact and Student's t-tests were performed for descriptive analyses. Multivariable logistic regression was used to examine associations between knowledge and practice, with the model adjusted by age of the PCP, geographic region, number of patients and years in practice. Analysis was performed in SAS version 9.4 (SAS Institute, Cary, NC, USA).

Results: A total of 382 PCPs were included in the analysis. The majority (60.0%) were males between the ages of 20-29 y (64.1%). Most PCPs (80.9%) reported that HPI is the cause of gastroesophageal reflux disease and 41.8% reported that HPI is the main cause of dyspeptic symptoms. The dominant diagnostic tests used for HPI were serology (52.8%) and stool antigen (30.9%). The most frequently used first-line therapies were amoxicillin (AMX), clarithromycin (CLA), metronidazole (MNZ) and proton pump inhibitor (PPI) concomitant therapy (32.2%), AMX-CLA-PPI triple therapy (18.6%) and AMX-MNZ-PPI triple therapy (13.1%). Half of the practitioners (48.6%) treat HPI empirically, without positive H. pylori testing. About half of the PCPs (48%) do not request laboratory confirmation of H. pylori eradication following treatment.

Conclusions: There is inadequate knowledge and significant differences in the clinical approach towards HPI among PCPs in Cameroon. We recommend more teaching programs and continuous medical education on HPI.

查看原文本刊更多论文

喀麦隆初级保健医生对幽门螺旋杆菌诊断和管理的知识和方法：一项横断面研究。

背景：中低收入国家幽门螺旋杆菌感染（HPI）的发病率很高。在喀麦隆，大多数幽门螺杆菌感染都是由初级保健医生（PCP）诊断和治疗的。我们试图评估喀麦隆初级保健医生在诊断和治疗幽门螺杆菌感染方面的知识和实践：方法：2021 年 11 月至 2022 年 6 月，我们在喀麦隆随机选取的四个地区开展了一项基于医院的横断面研究。在每个选定的地区，通过非概率便利抽样法招募初级保健医生，并使用预先设计的问卷进行访谈。对描述性分析进行了卡方检验、费雪精确检验和学生 t 检验。使用多变量逻辑回归分析知识与实践之间的关联，并根据初级保健医生的年龄、地理区域、患者人数和从业年限对模型进行调整。分析在 SAS 9.4 版（SAS Institute，Cary，NC，USA）中进行：共有 382 名初级保健医生参与了分析。大多数（60.0%）是男性，年龄在 20-29 岁之间（64.1%）。大多数初级保健医生（80.9%）称 HPI 是胃食管反流病的病因，41.8% 的初级保健医生称 HPI 是消化不良症状的主要病因。HPI 的主要诊断测试是血清学（52.8%）和粪便抗原（30.9%）。最常用的一线疗法是阿莫西林（AMX）、克拉霉素（CLA）、甲硝唑（MNZ）和质子泵抑制剂（PPI）联合疗法（32.2%）、AMX-CLA-PPI 三联疗法（18.6%）和 AMX-MNZ-PPI 三联疗法（13.1%）。半数医生（48.6%）在幽门螺杆菌检测结果呈阳性的情况下采用经验疗法治疗 HPI。大约一半的初级保健医生（48%）在治疗后不要求实验室确认幽门螺杆菌根除：结论：喀麦隆的初级保健医生对幽门螺杆菌感染的认识不足，临床治疗方法也存在显著差异。我们建议开展更多关于幽门螺杆菌感染的教学计划和持续医学教育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.