SPECT/CT, PET/CT, and PET/MRI for Response Assessment of Bone Metastases

IF 4.6 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in nuclear medicine Pub Date : 2024-05-01 DOI:10.1053/j.semnuclmed.2023.11.005

Nazanin Zamani-Siahkali MD , Seyed Ali Mirshahvalad MD, MPH, FEBNM , Abolfazl Farbod MD , Ghasemali Divband MD , Christian Pirich MD, PHD , Patrick Veit-Haibach MD , Gary Cook MBBS, MSC, MD , Mohsen Beheshti MD

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引用次数: 0

Abstract

Recent developments in hybrid SPECT/CT systems and the use of cadmium-zinc-telluride (CZT) detectors have improved the diagnostic accuracy of bone scintigraphy. These advancements have paved the way for novel quantitative approaches to accurate and reproducible treatment monitoring of bone metastases. PET/CT imaging using [¹⁸F]F-FDG and [¹⁸F]F-NaF have shown promising clinical utility in bone metastases assessment and monitoring response to therapy and prediction of treatment response in a broad range of malignancies. Additionally, specific tumor-targeting tracers like [^99mTc]Tc-PSMA, [⁶⁸Ga]Ga-PSMA, or [¹¹C]C- or [¹⁸F]F-Choline revealed high diagnostic performance for early assessment and prognostication of bone metastases, particularly in prostate cancer. PET/MRI appears highly accurate imaging modality, but has associated limitations notably, limited availability, more complex logistics and high installation costs. Advances in artificial intelligence (Al) seem to improve the accuracy of imaging modalities and provide an assistant role in the evaluation of treatment response of bone metastases.

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用于骨转移瘤反应评估的 SPECT/CT、PET/CT 和 PET/MRI。

混合 SPECT/CT 系统的最新发展和碲锌镉（CZT）探测器的使用提高了骨闪烁成像的诊断准确性。这些进步为采用新型定量方法对骨转移瘤进行准确、可重复的治疗监测铺平了道路。使用[18F]F-FDG 和[18F]F-NaF 的 PET/CT 成像在骨转移评估、治疗反应监测和预测多种恶性肿瘤的治疗反应方面显示出良好的临床应用前景。此外，[99mTc]Tc-PSMA、[68Ga]Ga-PSMA 或[11C]C-或[18F]F-胆碱等特异性肿瘤靶向示踪剂在骨转移的早期评估和预后方面显示出很高的诊断性能，尤其是在前列腺癌中。PET/MRI 似乎是非常准确的成像模式，但也有相关的局限性，特别是可用性有限、物流更复杂和安装成本高。人工智能（Al）的进步似乎提高了成像模式的准确性，并在评估骨转移瘤的治疗反应方面发挥了辅助作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in nuclear medicine 医学-核医学

CiteScore

9.80

自引率

6.10%

发文量

审稿时长

14 days

期刊介绍： Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.