Recent advances in antibody glycoengineering for the gain of functions

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-01-03 DOI:10.1016/j.cbpa.2023.102420

Zhi Liu , Xiangman Zou , Feng Tang , Wei Huang

引用次数: 0

Abstract

Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in mammalian cell expression systems, chemo-enzymatic antibody glycoengineering, and yeast expression system-based antibody engineering, as well as the applications of glycoengineering in antibody-drug conjugates. These advances in antibody glycoengineering will provide a comprehensive understanding and inspire us to develop more advanced techniques to achieve glycoengineered antibodies.

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为获得功能而进行抗体糖工程设计的最新进展

聚糖在抗体功能中发挥着重要作用，抗体糖工程长期以来一直是一个重要的研究领域。在此，我们总结了抗体糖工程的重要策略，包括哺乳动物细胞表达系统中的表达抗体糖工程、化学酶抗体糖工程和基于酵母表达系统的抗体工程，以及糖工程在抗体-药物共轭物中的应用。这些抗体糖工程方面的进展将为我们提供一个全面的认识，并启发我们开发更先进的技术来实现糖工程抗体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.