Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2024-01-02 DOI:10.1016/j.cytogfr.2023.12.007

Akey Krishna Swaroop , Preeya Negi , Ayushi Kar , Esakkimuthukumar Mariappan , Jawahar Natarajan , Krishnan Namboori P.K. , Jubie Selvaraj

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Abstract

This concise review navigates the intricate realm of Interleukin-6 (IL-6), an important member of the cytokine family. Beginning with an introduction to cytokines, this narrative review unfolds with the historical journey of IL-6, illuminating its evolving significance. A crucial section unravels the three distinct signaling modes employed by IL-6, providing a foundational understanding of its versatile interactions within cellular landscapes. Moving deeper, the review meticulously dissects IL-6's signaling mechanisms, unraveling the complexities of its pleiotropic effects in both physiological responses and pathological conditions. A significant focus is dedicated to the essential role IL-6 plays in inflammatory diseases, offering insights into its associations and implications for various health conditions. The review also takes a therapeutic turn by exploring the emergence of anti-IL-6 monoclonal inhibitors, marking a profound stride in treatment modalities. Diving into the molecular realm, the review explores small molecules as agents for IL-6 inhibition, providing a nuanced perspective on diverse intervention strategies. As the review embarks on the final chapters, it contemplates future aspects, offering glimpses into potential research trajectories and the evolving landscape of IL-6-related studies.

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IL-6导航：从分子机制到治疗突破。

白细胞介素-6 (IL-6)是细胞因子家族的重要成员，这篇简明扼要的综述将为您揭开其错综复杂的面纱。从介绍细胞因子开始，这篇叙述性综述展开了 IL-6 的历史进程，阐明了其不断演变的意义。其中一个重要部分揭示了 IL-6 所采用的三种不同的信号传导模式，为了解 IL-6 在细胞景观中的多功能相互作用提供了基础。更深入地看，这篇综述细致剖析了 IL-6 的信号转导机制，揭示了它在生理反应和病理条件下多重效应的复杂性。其中一个重点是 IL-6 在炎症性疾病中扮演的重要角色，深入探讨了其与各种健康状况的关联和影响。该综述还从治疗角度探讨了抗 IL-6 单克隆抑制剂的出现，这标志着治疗模式的一大进步。本综述深入分子领域，探讨了作为 IL-6 抑制剂的小分子，为各种干预策略提供了细致入微的视角。在综述的最后几章，它对未来进行了展望，提供了潜在研究轨迹的一瞥以及IL-6相关研究不断发展的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.