Thaís Evelyn Karnopp, Vinicius da Silva Freitas, Andressa Leite Di Domenico, Gustavo Flores Chapacais, Natália Garcia dos Santos, Eduarda Correa Freitas, Andrese Aline Gasparin, Odirlei André Monticielo
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引用次数: 0
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE.
系统性红斑狼疮（SLE）是一种可影响多个器官和系统的自身免疫性疾病。中枢和/或外周神经系统会出现并发症，即神经精神性狼疮（NPSLE）。研究表明，系统性红斑狼疮或非系统性红斑狼疮的表现与维生素 D 缺乏有关。研究表明，维生素D不足可导致非系统性红斑狼疮患者出现认知障碍和脑灌注不足。在这篇综述文章中，我们将讨论在非系统性红斑狼疮患者或动物模型中，维生素D补充或血清维生素D水平与神经精神表现相关的主要特征。
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