Shuangshuang Zhao , Chenglin Miao , Xuedi Gao , Zhifang Li , John E. Eriksson , Yaming Jiu
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引用次数: 0
Abstract
Vimentin, a type III intermediate filament, reorganizes into what is termed the ‘vimentin cage’ in response to various pathogenic infections. This cage-like structure provides an envelope to key components of the pathogen's life cycle. In viral infections, the vimentin cage primarily serves as a scaffold and organizer for the replication factory, promoting viral replication. However, it also occasionally contributes to antiviral functions. For bacterial infections, the cage mainly supports bacterial proliferation in most observed cases. These consistent structural alterations in vimentin, induced by a range of viruses and bacteria, highlight the vimentin cage's crucial role. Pathogen-specific factors add complexity to this interaction. In this review, we provide a thorough overview of the functions and mechanisms of the vimentin cage and speculate on vimentin's potential as a novel target for anti-pathogen strategies.
波形蛋白是一种 III 型中间丝，在各种病原体感染时会重组为所谓的 "波形蛋白笼"。这种笼状结构为病原体生命周期的关键组成部分提供了一个包膜。在病毒感染中，波形蛋白笼主要充当复制工厂的支架和组织者，促进病毒复制。不过，它偶尔也会发挥抗病毒功能。对于细菌感染，在大多数观察到的病例中，笼主要支持细菌增殖。由一系列病毒和细菌诱导的波形蛋白结构的这些一致改变，凸显了波形蛋白笼的关键作用。病原体特异性因素增加了这种相互作用的复杂性。在这篇综述中，我们全面概述了波形蛋白笼的功能和机制，并推测波形蛋白有可能成为抗病原体策略的新目标。
期刊介绍：
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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