Risk Factors for SARS-CoV-2 Among a Cohort of Healthcare Workers in Lebanon.

IF 2.3 4区 医学 Q1 NURSING
Workplace Health & Safety Pub Date : 2024-02-01 Epub Date: 2023-12-30 DOI:10.1177/21650799231214234
Carine J Sakr, Farouk F Abou Hassan, Lina Fakih, Mirna Bou Hamdan, Sara Assaf, Diana Rahme, Nada M Melhem
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引用次数: 0

Abstract

Background: Healthcare workers (HCWs) faced substantial risk of infection during the COVID-19 outbreak. This study aims to determine the prevalence of anti-SARS-CoV-2 antibodies in a cross-sectional sample of HCWs as well as risk factors associated with exposure to SARS-CoV-2.

Methods: The study was conducted between March and May 2021 at the American University of Beirut Medical Center (AUBMC), a tertiary hospital located in Lebanon. Socio-demographic and clinical data, as well as data on exposure, PCR results, PPE adherence, and vaccination status, were collected using an online questionnaire. Sera were also collected to determine seropositivity using commercially available enzyme-linked immunoassay (ELISA) targeting the spike (S) and the nucleocapsid proteins (NCP) of SARS-CoV-2.

Findings: Among 92 recruited HCWs, 72.3% received PPE training, more than 70% were adherent to using appropriate PPEs, and around 80% were vaccinated. Nurses in this study population were at higher risk of exposure compared to medical doctors, technicians, and other HCWs. Among the HCWs who performed a PCR test, 28.6% were infected with SARs-CoV-2 with workplace exposure not associated with COVID-19 infection. All vaccinated HCWs were seropositive for anti-S IgG with high titer (≥384 BAU/mL), with a significantly higher median anti-S IgG titer compared to unvaccinated HCWs with previous infection (384 vs. 140.1 BAU/mL; p = .0043).

Conclusions: Our study highlights the importance of implementing strict infection control policies among HCWs and deploying an effective COVID-19 vaccination strategy. More studies are needed in Lebanon to assess risk factors of SARS-CoV-2 exposure in the workplace.

黎巴嫩医护人员感染 SARS-CoV-2 的风险因素。
背景:在 COVID-19 爆发期间,医护人员(HCWs)面临着巨大的感染风险。本研究旨在确定医护人员横断面样本中抗 SARS-CoV-2 抗体的流行率以及与接触 SARS-CoV-2 相关的风险因素:研究于 2021 年 3 月至 5 月在黎巴嫩的一家三级医院贝鲁特美国大学医学中心(AUBMC)进行。研究人员通过在线问卷调查收集了社会人口学和临床数据,以及有关接触、PCR 结果、个人防护设备使用情况和疫苗接种情况的数据。此外,还收集了血清,使用市售的针对 SARS-CoV-2 的尖峰蛋白(S)和核壳蛋白(NCP)的酶联免疫测定法(ELISA)确定血清阳性率:在 92 名被招募的医护人员中,72.3% 的人接受过个人防护设备培训,70% 以上的人坚持使用适当的个人防护设备,约 80% 的人接种了疫苗。与医生、技术人员和其他医护人员相比,本研究人群中的护士接触风险更高。在进行 PCR 检测的医务人员中,28.6% 感染了 SARs-CoV-2,而工作场所暴露与 COVID-19 感染无关。所有接种过疫苗的高危工人的抗 S IgG 血清阳性,滴度较高(≥384 BAU/mL),与未接种过疫苗且曾感染过的高危工人相比,抗 S IgG 滴度中位数明显更高(384 vs. 140.1 BAU/mL;p = .0043):我们的研究强调了在医护人员中实施严格的感染控制政策和部署有效的 COVID-19 疫苗接种策略的重要性。需要在黎巴嫩开展更多研究,以评估工作场所接触 SARS-CoV-2 的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
3.80%
发文量
77
审稿时长
6-12 weeks
期刊介绍: Workplace Health & Safety: Promoting Environments Conducive to Well-Being and Productivity is the official publication of the American Association of Occupational Health Nursing, Inc. (AAOHN). It is a scientific peer-reviewed Journal. Its purpose is to support and promote the practice of occupational and environmental health nurses by providing leading edge research findings and evidence-based clinical practices. It publishes articles that span the range of issues facing occupational and environmental health professionals, including emergency and all-hazard preparedness, health promotion, safety, productivity, environmental health, case management, workers'' compensation, business and leadership, compliance and information management.
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