The significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease.

IF 5.1 4区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Precision Clinical Medicine Pub Date : 2023-12-11 eCollection Date: 2023-12-01 DOI:10.1093/pcmedi/pbad031
Fei Jiang, Min Wu, Rongpeng Li
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引用次数: 0

Abstract

Inflammatory bowel diseases (IBD) are a group of chronic relapsing gastrointestinal inflammatory diseases with significant global incidence. Although the pathomechanism of IBD has been extensively investigated, several aspects of its pathogenesis remain unclear. Long non-coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides in length that have potential protein-coding functions. LncRNAs play important roles in biological processes such as epigenetic modification, transcriptional regulation and post-transcriptional regulation. In this review, we summarize recent advances in research on IBD-related lncRNAs from the perspective of the overall intestinal microenvironment, as well as their potential roles as immune regulators, diagnostic biomarkers and therapeutic targets or agents for IBD.

长非编码 RNA 在炎症性肠病的发病机制、诊断和治疗中的意义。
炎症性肠病(IBD)是一组慢性复发性胃肠道炎症性疾病,在全球发病率很高。虽然 IBD 的病理机制已被广泛研究,但其发病机制的几个方面仍不清楚。长非编码 RNA(lncRNA)是长度超过 200 个核苷酸的转录本,具有潜在的蛋白质编码功能。LncRNA 在表观遗传修饰、转录调控和转录后调控等生物过程中发挥着重要作用。在这篇综述中,我们从整体肠道微环境的角度总结了与 IBD 相关的 lncRNA 的最新研究进展,以及它们作为免疫调节剂、诊断生物标志物和 IBD 治疗靶标或药物的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Precision Clinical Medicine
Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
10.80
自引率
0.00%
发文量
26
审稿时长
5 weeks
期刊介绍: Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.
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