Morphometric, biochemical and histopathological effects of sofosbuvir (sovaldi) on testes of adult male albino rats.

IF 1.1 4区医学 Q4 MICROSCOPY

Ultrastructural Pathology Pub Date : 2024-03-03 Epub Date: 2024-02-07 DOI:10.1080/01913123.2023.2295453

Safaa M H Abdelaziz

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Abstract

Sofosbuvir treatment regimens for chronic HCV infection have recently been linked to extra hepatic side effects. This study aimed to show how sofosbuvir affected the adult male albino rat testis. Forty adult male albino rats were used. The rats were equally split into two main groups (I and II), then each group subdivided into two subgroups (A and B). Each rat in group I (control) received 0.5 ml of distilled water every day for four weeks. Each rat in group II (sofosbuvir-treated) received 0.5 ml of distilled water containing 7.2 mg of sofosbuvir every day for four weeks. After four weeks (subgroups IA and IIA) and eight weeks (subgroups IB and IIB) of treatment, the rats were sacrificed. Histological, biochemical, and morphometric studies on the testes were conducted. The data were analyzed. Examination of testes of sovaldi treated group revealed histopathological changes. Biochemical and morphometric analysis showed reduced levels of reduced glutathione and seminiferous tubule epithelial height respectively. Following a 4-week drug withdrawal period, the testes only partially recovered. We concluded that sofosbuvir induced deteriorating changes in the adult male albino rats' testes. These changes were proved by histological and biochemical studies. These changes were incompletely reversible after cession of treatment. Researches investigating the effect of adding drugs that have antioxidant properties during sofosbuvir therapy are recommended.

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索非布韦（sovaldi）对成年雄性白化大鼠睾丸的形态学、生物化学和组织病理学影响

索非布韦治疗慢性丙型肝炎病毒感染的方案最近与肝脏副作用有关。本研究旨在说明索非布韦对成年雄性白化大鼠睾丸的影响。研究使用了 40 只成年雄性白化大鼠。这些大鼠被平均分成两大组（I 组和 II 组），然后每组又被细分成两个亚组（A 组和 B 组）。I 组（对照组）的每只大鼠每天饮用 0.5 毫升蒸馏水，连续四周。II组（索非布韦治疗组）的每只大鼠每天饮用0.5毫升含有7.2毫克索非布韦的蒸馏水，持续四周。治疗四周（IA 和 IIA 亚组）和八周（IB 和 IIB 亚组）后，大鼠被处死。对睾丸进行组织学、生物化学和形态计量学研究。对数据进行了分析。索华迪治疗组睾丸的检查显示了组织病理学变化。生化和形态分析表明，还原型谷胱甘肽水平和曲细精管上皮高度分别降低。停药4周后，睾丸仅部分恢复。我们的结论是，索非布韦会导致成年雄性白化大鼠的睾丸发生恶化性变化。组织学和生化研究证实了这些变化。这些变化在停止治疗后不完全可逆。建议开展研究，探讨在索非布韦治疗期间添加具有抗氧化特性的药物的效果。

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来源期刊

Ultrastructural Pathology 医学-病理学

CiteScore

2.00

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ultrastructural Pathology is the official journal of the Society for Ultrastructural Pathology. Published bimonthly, we are the only journal to be devoted entirely to diagnostic ultrastructural pathology. Ultrastructural Pathology is the ideal journal to publish high-quality research on the following topics: Advances in the uses of electron microscopic and immunohistochemical techniques Correlations of ultrastructural data with light microscopy, histochemistry, immunohistochemistry, biochemistry, cell and tissue culturing, and electron probe analysis Important new, investigative, clinical, and diagnostic EM methods.