Discriminative value of pulse wave velocity for arterial stiffness and cardiac injury in prediabetic patients.

IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE

Jornal Vascular Brasileiro Pub Date : 2023-12-11 eCollection Date: 2023-01-01 DOI:10.1590/1677-5449.202300762

Stella Maris Firmino, Cássia da Luz Goulart, João Paulo Gregorio, Klaus Werner Wende, Fernanda Yuri Yuamoto, Lana Kummer, Emílio Martins Curcelli, Alessandro Domingues Heubel, Erika Zavaglia Kabbach, Polliana Batista Santos, Audrey Borghi-Silva, Renata Gonçalves Mendes, Ângela Mérice de Oliveira Leal, Meliza Goi Roscani

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引用次数: 0

Abstract

Background: Prediabetes (PD) is defined as impaired fasting glucose and/or impaired glucose tolerance (IGT) and may be associated with high risk of cardiovascular injury. It is recommended that PD patients be screened for signs of arterial stiffness and cardiovascular injury to reinforce therapeutic strategies.

Objectives: To identify pulse wave velocity values discriminative for arterial stiffness and cardiovascular injury in PD patients.

Methods: A cross-sectional study was conducted with PD (N=43) and normoglycemic (N=37) patients who underwent clinical evaluation, arterial stiffness assessment by carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor, laboratory blood analysis, investigation of morphological and functional cardiac variables by transthoracic echocardiogram, and assessment of carotid intima-media-thickness (CIMT) by carotid ultrasonography. A statistical analysis was performed using SPSS software and values of p<0.05 were considered significant.

Results: A cfPWV cut-off value of 6.9 m/s was identified for IGT (Sensitivity [SE]: 74% and Specificity [SP]: 51%). Comparison of general data and risk factors between subsets with values above and below this cutoff value revealed higher rates of fasting glucose (p=0.02), obesity (p=0.03), dyslipidemia (p=0.004), early signs of left ventricle (p=0.017) and right ventricle (p=0.03) impaired diastolic function, and elevated CIMT in subjects with cfPWV ≥ 6.9m/s (p=0.04).

Conclusions: In PD patients, a cfPWV cutoff of 6.9 m/s was considered a discriminative value for arterial stiffness. These findings highlight the value of early investigation of cardiovascular injury and aggressive therapy strategies with good control of risk factors in PD.

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脉搏波速度对糖尿病前期患者动脉僵化和心脏损伤的鉴别价值。

背景：糖尿病前期（PD）是指空腹血糖受损和/或糖耐量受损（IGT），可能与心血管损伤的高风险有关。建议对糖尿病前期患者进行动脉僵化和心血管损伤迹象筛查，以加强治疗策略：确定脉搏波速度值对帕金森病患者动脉僵化和心血管损伤的鉴别作用：方法：对接受临床评估、使用 SphygmoCor 通过颈动脉-股动脉脉搏波速度（cfPWV）进行动脉僵化评估、实验室血液分析、通过经胸超声心动图检查心脏形态和功能变量以及通过颈动脉超声波检查颈动脉内膜中层厚度（CIMT）的 PD（43 例）和血糖正常（37 例）患者进行横断面研究。使用 SPSS 软件进行了统计分析，并得出了 pResults 值：IGT的cfPWV临界值为6.9 m/s（敏感性[SE]：74%，特异性[SP]：51%）。比较高于和低于该临界值的子集的一般数据和风险因素，发现在 cfPWV ≥ 6.9m/s 的受试者中，空腹血糖（p=0.02）、肥胖（p=0.03）、血脂异常（p=0.004）、左心室（p=0.017）和右心室（p=0.03）舒张功能受损的早期症状以及 CIMT 升高（p=0.04）的比例较高：在帕金森病患者中，6.9 m/s的cfPWV临界值被认为是动脉僵化的鉴别值。这些发现凸显了早期调查心血管损伤和积极治疗策略的价值，并能很好地控制帕金森病的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Vascular Brasileiro Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Vascular Brasileiro is editated and published quaterly to select and disseminate high-quality scientific contents concerning original research, novel surgical and diagnostic techniques, and clinical observations in the field of vascular surgery, angiology, and endovascular surgery. Its abbreviated title is J. Vasc. Bras., which should be used in bibliographies, footnotes and bibliographical references and strips.