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{"title":"Renal Epithelial Mitochondria: Implications for Hypertensive Kidney Disease.","authors":"Krisztian Stadler, Daria V Ilatovskaya","doi":"10.1002/cphy.c220033","DOIUrl":null,"url":null,"abstract":"<p><p>According to the Centers for Disease Control and Prevention, 1 in 2 U.S. adults have hypertension, and more than 1 in 7 chronic kidney disease. In fact, hypertension is the second leading cause of kidney failure in the United States; it is a complex disease characterized by, leading to, and caused by renal dysfunction. It is well-established that hypertensive renal damage is accompanied by mitochondrial damage and oxidative stress, which are differentially regulated and manifested along the nephron due to the diverse structure and functions of renal cells. This article provides a summary of the relevant knowledge of mitochondrial bioenergetics and metabolism, focuses on renal mitochondrial function, and discusses the evidence that has been accumulated regarding the role of epithelial mitochondrial bioenergetics in the development of renal tissue dysfunction in hypertension. © 2024 American Physiological Society. Compr Physiol 14:5225-5242, 2024.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194858/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220033","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
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Abstract
According to the Centers for Disease Control and Prevention, 1 in 2 U.S. adults have hypertension, and more than 1 in 7 chronic kidney disease. In fact, hypertension is the second leading cause of kidney failure in the United States; it is a complex disease characterized by, leading to, and caused by renal dysfunction. It is well-established that hypertensive renal damage is accompanied by mitochondrial damage and oxidative stress, which are differentially regulated and manifested along the nephron due to the diverse structure and functions of renal cells. This article provides a summary of the relevant knowledge of mitochondrial bioenergetics and metabolism, focuses on renal mitochondrial function, and discusses the evidence that has been accumulated regarding the role of epithelial mitochondrial bioenergetics in the development of renal tissue dysfunction in hypertension. © 2024 American Physiological Society. Compr Physiol 14:5225-5242, 2024.
肾上皮线粒体:对高血压肾病的影响
根据美国疾病控制和预防中心的数据,每 2 个美国成年人中就有 1 人患有高血压,每 7 人中就有 1 人患有慢性肾病。事实上,在美国,高血压是导致肾衰竭的第二大原因;高血压是一种复杂的疾病,其特点是肾功能不全,导致肾功能不全,并由肾功能不全引起。高血压肾损伤伴随着线粒体损伤和氧化应激,由于肾细胞结构和功能的多样性,线粒体损伤和氧化应激在肾小管中的调节和表现各不相同,这一点已得到公认。本文总结了线粒体生物能和代谢的相关知识,重点关注肾线粒体功能,并讨论了有关上皮线粒体生物能在高血压肾组织功能障碍发展过程中的作用所积累的证据。© 2024 美国生理学会。Compr Physiol 14:5225-5242, 2024.
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