Periconceptional Serum Creatinine and Risk of Childhood Autism Spectrum Disorder: A Research Letter.

IF 1.6 Q3 UROLOGY & NEPHROLOGY
Canadian Journal of Kidney Health and Disease Pub Date : 2023-12-29 eCollection Date: 2024-01-01 DOI:10.1177/20543581231221892
Ziv Harel, Nivethika Jeyakumar, Yuguang Kang, Maria P Velez, Natalie Dayan, Joel G Ray
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引用次数: 0

Abstract

Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition that manifests in early childhood, in which the maternal metabolic syndrome may be a risk factor. The kidney is a barometer of maternal metabolic syndrome duration and severity.

Objective: The main objective of this study is to determine whether periconceptional kidney function is associated with ASD in early childhood.

Design setting and participants: This retrospective population-based cohort study was completed in Ontario, Canada. Included were singleton children born in an Ontario hospital between April 2007 and March 2021, who were alive at age 48 months and whose mother had a recorded prepregnancy body mass index (BMI) and a measured serum creatinine (SCr) between 120 days preconception and 28 days postconception.

Measurement: The main study outcome was a diagnosis of ASD between ages 24 and 48 months.

Methods: Relative risks (RRs) of ASD in association with periconceptional SCr were generated using modified Poisson regression and adjusted for several confounders.

Results: The cohort comprised 86 054 women, who had 89 677 liveborn children surviving to at least 48 months of age. There was no significant association between periconceptional SCr and ASD (RR: 0.86; 95 % confidence interval: [0.67, 1.10]).

Limitations: Selection bias may have arisen had SCr been ordered on clinical grounds.

Conclusions: Further study is warranted to determine whether prepregnancy glomerular hyperfiltration is a marker of ASD and other behavioral conditions in childhood. To do so, a more accurate measure of hyperfiltration is needed than SCr.

围孕期血清肌酸酐与儿童自闭症谱系障碍的风险:一封研究信。
背景:自闭症谱系障碍(ASD)是一种在儿童早期表现出来的神经发育疾病,母亲代谢综合征可能是其中的一个风险因素。肾脏是母亲代谢综合征持续时间和严重程度的晴雨表:本研究的主要目的是确定围孕期肾功能是否与幼儿期 ASD 相关:这项基于人群的回顾性队列研究在加拿大安大略省完成。研究对象包括 2007 年 4 月至 2021 年 3 月期间在安大略省一家医院出生的单胎儿童,这些儿童在 48 个月大时仍然存活,其母亲在孕前 120 天至孕后 28 天期间有记录的孕前体重指数(BMI)和测量的血清肌酐(SCr):主要研究结果是 24 至 48 个月期间 ASD 的诊断结果:采用改良泊松回归法得出ASD与围孕期SCr相关的相对风险(RR),并对几种混杂因素进行了调整:队列由 86 054 名妇女组成,其中 89 677 名活产儿存活至至少 48 个月大。围孕期 SCr 与 ASD 之间无明显关联(RR:0.86;95 % 置信区间:[0.67, 1.10]):局限性:如果SCr是基于临床理由下达的,则可能会出现选择偏差:有必要进行进一步研究,以确定孕前肾小球高滤过是否是 ASD 和儿童期其他行为问题的标志。为此,需要一种比 SCr 更准确的高滤过测量方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.00
自引率
5.90%
发文量
84
审稿时长
12 weeks
期刊介绍: Canadian Journal of Kidney Health and Disease, the official journal of the Canadian Society of Nephrology, is an open access, peer-reviewed online journal that encourages high quality submissions focused on clinical, translational and health services delivery research in the field of chronic kidney disease, dialysis, kidney transplantation and organ donation. Our mandate is to promote and advocate for kidney health as it impacts national and international communities. Basic science, translational studies and clinical studies will be peer reviewed and processed by an Editorial Board comprised of geographically diverse Canadian and international nephrologists, internists and allied health professionals; this Editorial Board is mandated to ensure highest quality publications.
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