{"title":"Design of a Nanozyme−Based Magnetic Nanoplatform to Enhance Photodynamic Therapy and Immunotherapy","authors":"Chen Bai, Jiajing Liu, Luyao Bai, Dapeng Yao, Xiaofeng Li, Haoran Zhang, Dong Guo","doi":"10.1016/j.jpha.2023.12.018","DOIUrl":null,"url":null,"abstract":"<p>The tumor microenvironment, particularly the hypoxic property and glutathione (GSH) overexpression, substantially inhibits the efficacy of cancer therapy. In this article, we present the design of a magnetic nanoplatform (MNPT) comprised of a photosensitizer (Ce6) and an iron oxide (Fe<sub>3</sub>O<sub>4</sub>)/manganese oxide (MnO<sub>2</sub>) composite nanozyme. Reactive oxygen species (ROS), such as singlet oxygen (<sup>1</sup>O<sub>2</sub>) radicals produced by light irradiation and hydroxyl radicals (·OH) produced by catalysis, are therapeutic species. These therapeutic substances stimulate cell apoptosis by increasing oxidative stress. This apoptosis then triggers the immunological response, which combines photodynamic therapy and T−cell−mediated immunotherapy to treat cancer. Furthermore, MNPT can be utilized as a contrast agent in magnetic resonance and fluorescence dual−modality imaging to give real−time tracking and feedback on treatment.</p>","PeriodicalId":16737,"journal":{"name":"Journal of Pharmaceutical Analysis","volume":"7 1","pages":""},"PeriodicalIF":6.1000,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Analysis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jpha.2023.12.018","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
The tumor microenvironment, particularly the hypoxic property and glutathione (GSH) overexpression, substantially inhibits the efficacy of cancer therapy. In this article, we present the design of a magnetic nanoplatform (MNPT) comprised of a photosensitizer (Ce6) and an iron oxide (Fe3O4)/manganese oxide (MnO2) composite nanozyme. Reactive oxygen species (ROS), such as singlet oxygen (1O2) radicals produced by light irradiation and hydroxyl radicals (·OH) produced by catalysis, are therapeutic species. These therapeutic substances stimulate cell apoptosis by increasing oxidative stress. This apoptosis then triggers the immunological response, which combines photodynamic therapy and T−cell−mediated immunotherapy to treat cancer. Furthermore, MNPT can be utilized as a contrast agent in magnetic resonance and fluorescence dual−modality imaging to give real−time tracking and feedback on treatment.
肿瘤微环境，尤其是缺氧特性和谷胱甘肽（GSH）过度表达，严重抑制了癌症治疗的效果。本文介绍了由光敏剂（Ce6）和氧化铁（Fe3O4）/氧化锰（MnO2）复合纳米酶组成的磁性纳米平台（MNPT）的设计。光照射产生的单线态氧（1O2）自由基和催化产生的羟自由基（-OH）等活性氧物种（ROS）是治疗物种。这些治疗物质通过增加氧化应激刺激细胞凋亡。细胞凋亡会引发免疫反应，从而将光动力疗法和 T 细胞介导的免疫疗法结合起来治疗癌症。此外，MNPT 还可用作磁共振和荧光双模态成像的造影剂，对治疗进行实时跟踪和反馈。
期刊介绍：
The Journal of Pharmaceutical Analysis (JPA), established in 2011, serves as the official publication of Xi'an Jiaotong University.
JPA is a monthly, peer-reviewed, open-access journal dedicated to disseminating noteworthy original research articles, review papers, short communications, news, research highlights, and editorials in the realm of Pharmacy Analysis. Encompassing a wide spectrum of topics, including Pharmaceutical Analysis, Analytical Techniques and Methods, Pharmacology, Metabolism, Drug Delivery, Cellular Imaging & Analysis, Natural Products, and Biosensing, JPA provides a comprehensive platform for scholarly discourse and innovation in the field.
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