Molecular epidemiology of human metapneumovirus before and after COVID-19 in East Japan in 2017–2022

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Japanese journal of infectious diseases Pub Date : 2023-12-28 DOI:10.7883/yoken.jjid.2023.350

Kazuya Shirato, Reiko Suwa, Naganori Nao, Miyuki Kawase, Satoko Sugimoto, Yohei Kume, Mina Chishiki, Takashi Ono, Hisao Okabe, Sakurako Norito, Masatoki Sato, Hiroko Sakuma, Shigeo Suzuki, Mitsuaki Hosoya, Makoto Takeda, Koichi Hashimoto

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引用次数: 0

Abstract

Human metapneumovirus (hMPV) is genetically classified into two major subgroups, A and B, based on attachment glycoprotein (G) gene sequences, and the A2 subgroup is further separated into three subdivisions A2a, A2b (A2b1), and A2c (A2b2). The appearance of subgroup A2c viruses carrying a 180- or 111-nucleotide duplication in the G gene (A2c_180nt-dup or A2c_111nt-dup) have been reported in Japan and Spain. The pandemic of coronavirus disease 2019 (COVID-19) disrupted the epidemiological kinetics of other respiratory viruses, including hMPV. In this study, we analysed the sequences of hMPV isolates obtained from 2017 to 2022 in Tokyo and Fukushima, i.e., before and after COVID-19. Subgroup A hMPVs were detected in 2017 to 2019, and most cases were A2c_111nt-dup, suggesting there was continuous momentum of this clade, identical to the global situation. Subgroup B, but not subgroup A, viruses were detected in 2022, after the COVID-19 peak. Phylogenetic analysis showed that these resumed subgroup B viruses were closely related to the viruses detected in 2013 to 2016 in Yokohama and in 2019 in Fukushima, suggesting a reappearance of local endemic viruses in East Japan.

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2017-2022 年 COVID-19 前后东日本人类偏肺病毒的分子流行病学

根据附着糖蛋白（G）基因序列，人类偏肺病毒（hMPV）在基因上可分为 A 和 B 两大亚群，A2 亚群又分为 A2a、A2b（A2b1）和 A2c（A2b2）三个分支。据报道，日本和西班牙出现了在 G 基因中携带 180 或 111 个核苷酸重复序列（A2c180nt-dup 或 A2c111nt-dup）的 A2c 亚群病毒。2019 年冠状病毒病大流行（COVID-19）扰乱了包括 hMPV 在内的其他呼吸道病毒的流行动力学。在本研究中，我们分析了 2017 年至 2022 年（即 COVID-19 之前和之后）在东京和福岛获得的 hMPV 分离物序列。2017 年至 2019 年期间检测到了 A 亚群 hMPV，大多数病例为 A2c111nt-dup，这表明该支系的发展势头与全球情况相同。在 COVID-19 高峰之后的 2022 年，发现了 B 亚群病毒，但没有发现 A 亚群病毒。系统发生学分析表明，这些恢复的 B 亚群病毒与 2013 年至 2016 年在横滨和 2019 年在福岛检测到的病毒密切相关，这表明东日本再次出现了地方流行病毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese journal of infectious diseases 医学-传染病学

CiteScore

4.50

自引率

4.50%

发文量

172

审稿时长

2 months

期刊介绍： Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.