Relationship between falls and the use of hypnotics, antidepressants, antipsychotics, and anxiolytics in patients with rheumatoid arthritis: A cross-sectional study.

IF 1.8 4区医学 Q3 RHEUMATOLOGY

Modern Rheumatology Pub Date : 2024-12-25 DOI:10.1093/mr/road118

Kosuke Sakurai, Ryo Yanai, Takeo Isozaki, Nobuyuki Yajima

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引用次数: 0

Abstract

Objectives: This cross-sectional study aimed to determine the relationship between falls and the use of psychotropic medications in patients with rheumatoid arthritis (RA).

Methods: The psychotropic medication group included patients with RA prescribed psychotropic medications [hypnotics/sedatives, antidepressants, antipsychotics, and anxiolytic (benzodiazepines) drugs]. Poisson regression with robust variance was performed to investigate the relationship between falls and the use of psychotropic medications, with adjustment for age, sex, RA disease activity, stroke, dementia, diabetes mellitus, and osteoarthritis.

Results: Of the 307 patients enrolled, 49 (16.0%) used psychotropic medications and 70 (22.8%) experienced at least one fall per year. Nineteen of the 49 patients (38.8%) taking psychotropic medications and 51 of 258 (19.8%) not taking psychotropic medications experienced at least one fall per year. Falls were significantly more frequent in the group with psychotropic medications than in the group without psychotropic medications (adjusted incidence rate ratio, 1.63; 95% confidence interval, 1.08-2.48; P = .02). No relationship was found between the number of falls and the use of psychotropic medications (adjusted incidence rate ratio, 1.16; 95% confidence interval, 0.39-3.44; P = .78).

Conclusions: There may be a relationship between psychotropic medication use and falls in patients with RA.

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类风湿性关节炎患者跌倒与使用催眠药、抗抑郁药、抗精神病药和抗焦虑药之间的关系：一项横断面研究。

目的本横断面研究旨在确定类风湿关节炎患者跌倒与精神药物使用之间的关系。方法精神药物组包括服用精神药物（催眠药/镇静剂、抗抑郁药、抗精神病药和抗焦虑药[苯二氮卓类药物]）的类风湿性关节炎患者。在对年龄、性别、类风湿性关节炎疾病活动度、中风、痴呆、糖尿病和骨关节炎进行调整后，采用稳健方差泊松回归法研究跌倒与精神药物使用之间的关系。结果在登记的 307 名患者中，49 人（16.0%）使用精神药物，70 人（22.8%）每年至少摔倒一次。在 49 名服用精神药物的患者中，有 19 人（38.8%）每年至少摔倒一次；在 258 名未服用精神药物的患者中，有 51 人（19.8%）每年至少摔倒一次。服用精神药物组的跌倒发生率明显高于未服用精神药物组（调整后的发生率比为 1.63；95% 置信区间为 1.08-2.48，P = 0.02）。跌倒次数与使用精神药物之间没有关系（调整后发病率比为 1.16；95% 置信区间为 0.39-3.44，P = 0.78）。结论类风湿性关节炎患者服用精神药物与跌倒之间可能存在关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions