Evaluating the effect of cow's milk fortified with albumin powder on malnutrition and anthropometric indices in primary-school children with mild-to-moderate underweight: A randomized double-blinded clinical trial.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2023-10-26 eCollection Date: 2023-01-01 DOI:10.4103/jrms.jrms_69_21

Hajar Davarpanah, Roxaneh Sadat Ziaee, Zahra Esmaeilinezhad, Peyman Etemadfar, Javad Hematyar, Siavash Babajafari, Reza Barati-Boldaji

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引用次数: 0

Abstract

Background: A proper diet plan is one of the necessary conditions for maintaining the children's health. The aim of this study was to evaluate the effect of consumption of pasteurized cow's milk fortified with albumin protein in primary-school children, in Yasuj, Iran.

Materials and methods: In this double-blind randomized clinical trial with 12 weeks of duration, 60 children aged 7-13 years, mild to moderate underweight (-1≥ weight-for-age z-score ≥-3), were randomly assigned to control and albumin groups. The albumin group and the control group received 200 cc of milk with 10 g of albumin powder and 200 cc of milk with 10 g of cornstarch powder, respectively. At the beginning and end of the study, food intake and anthropometric indices were measured.

Results: After 12 weeks of intervention, none of the anthropometric indices (weight, weight-for-age z-score, body mass index (BMI), BMI-for-age z-score, and waist circumference) showed significant changes as compared to baseline in the control group, but weight-for-age z-score and BMI-for-age z-score showed significant increase as compared to baseline in the albumin group (before: -2.25 ± 0.40, after: -1.98 ± 0.35, P = 0.001 and before: -3.48 ± 0.86, after: -3.06 ± 0.71, P = 0.009, respectively). The comparison of the mean changes between the two groups showed significant difference regarding weight-for-age z-score (control group: -1.70 ± 0.31 in comparison with albumin group: -1.98 ± 0.35, P = 0.002), BMI (control group: 12.08 ± 1.96 in comparison with albumin group: 12.13 ± 1.49, P = 0.03), and BMI-for-age z-score (control group: -3.11 ± 0.91 in comparison with albumin group: -3.06 ± 0.71, P = 0.02).

Conclusion: The consumption of albumin powder with milk can improve weight-for-age z-score and BMI-for-age z-score indices in children with mild-to-moderate underweight. Larger controlled interventional studies with longer duration are recommended.

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评估添加白蛋白粉的牛奶对轻度至中度体重不足的小学生营养不良和人体测量指数的影响：随机双盲临床试验。

背景：合理的饮食计划是保持儿童健康的必要条件之一。本研究的目的是评估伊朗亚苏杰地区小学生饮用强化了白蛋白的巴氏杀菌牛奶的效果：在这项为期 12 周的双盲随机临床试验中，60 名 7-13 岁轻度至中度体重不足（-1≥ 体重-年龄 Z 值≥-3）的儿童被随机分配到对照组和白蛋白组。白蛋白组和对照组分别饮用 200 cc 含有 10 克白蛋白粉的牛奶和 200 cc 含有 10 克玉米淀粉粉的牛奶。在研究开始和结束时，测量了食物摄入量和人体测量指数：干预 12 周后，对照组的人体测量指数（体重、体重-年龄 Z 值、体重指数（BMI）、体重指数-年龄 Z 值和腰围）与基线相比均无显著变化，但白蛋白组的体重-年龄 Z 值和体重指数-年龄 Z 值与基线相比有显著增加（干预前：-2.25 ± 0.40，干预后：-1.98 ± 0.35，干预前：-1.98 ± 0.35，干预后：-1.98 ± 0.35）：前：-2.25 ± 0.40，后：-1.98 ± 0.35，P = 0.001；前：-3.48 ± 0.86，后：-3.06 ± 0.71，P = 0.001：前：-3.48 ± 0.86，后：-3.06 ± 0.71，P = 0.009）。对照组：12.08 ± 1.96，白蛋白组：12.13 ± 1.49，P = 0.002：结论：结论：在牛奶中添加白蛋白粉可以改善轻度至中度体重不足儿童的体重年龄Z值和体重指数年龄Z值。建议进行更大规模、持续时间更长的对照干预研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.