Occurrence of bisphosphonate-associated osteonecrosis of the jaws in individuals with rheumatoid arthritis - a systematic review.

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2024-05-01 DOI:10.4317/medoral.26373

J-R Tenório, D Estanho, L-S Silva, A-V Pintor, M-B Magno, I-L Cavalcante, B-A Andrade, L-C Maia

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Abstract

Background: To access the occurrence of bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in individuals with rheumatoid arthritis (RA).

Material and methods: Observational studies that evaluated the occurrence of BAONJ in individuals with RA (BAONJ-RA) were considered for inclusion. Electronic searches were performed up to December 2022 in six databases and in the grey literature. The study selection, data extraction, and quality assessment of the included studies according to the Joanna Briggs Institute Critical Appraisal Checklists was performed. The certainty of evidence was evaluated using the GRADE approach.

Results: Five studies were included three cohort and two cross-sectional. The sample size of subjects with RA ranged from 16 to 3201. Together, the studies presented 36 cases of BAONJ-RA. Prevalence of BAONJ-RA ranged from 0.094% to 56.25%. The incidence ranged from 0.4% to 2.21. Women between the 6th and 8th decade of life were the most affected. Alendronate (n=5) and zoledronic acid (n=9), orally and intravenously, respectively, were the most used bisphosphonates. The duration of bisphosphonates use ranged from 2.7 to 8 years. The certainty of evidence was very low.

Conclusions: The occurrence of BAONJ-RA is low. However, the certainty of the evidence was very low for this outcome.

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类风湿性关节炎患者发生双膦酸盐相关性颌骨坏死--系统综述。

背景：了解类风湿性关节炎（RA）患者双膦酸盐相关性颌骨坏死（BAONJ）的发生情况：目的：了解类风湿性关节炎（RA）患者发生双膦酸盐相关性颌骨坏死（BAONJ）的情况：考虑纳入评估类风湿性关节炎患者（BAONJ-RA）颌骨坏死发生率的观察性研究。截至 2022 年 12 月，在六个数据库和灰色文献中进行了电子检索。根据乔安娜-布里格斯研究所（Joanna Briggs Institute）的关键评估检查表对纳入的研究进行了选择、数据提取和质量评估。采用 GRADE 方法对证据的确定性进行了评估：共纳入了五项研究，其中三项为队列研究，两项为横断面研究。RA受试者的样本量从16到3201不等。这些研究共发现了 36 例 BAONJ-RA。BAONJ-RA 的患病率从 0.094% 到 56.25% 不等。发病率从 0.4% 到 2.21% 不等。受影响最大的是 6 至 8 岁的女性。阿仑膦酸钠（5 人）和唑来膦酸（9 人）分别是口服和静脉注射使用最多的双膦酸盐。使用双膦酸盐的时间从 2.7 年到 8 年不等。证据的确定性很低：结论：BAONJ-RA的发生率很低。结论：BAONJ-RA的发生率较低，但该结果的证据确定性很低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology