GABAA Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-01-01 Epub Date: 2023-12-27 DOI:10.1159/000535512
Linda Steinholtz, Elin Thörnblom, Robert Bodén, Anders Wall, Hans W Axelson, Mark Lubberink, David Fällmar, Jonas Persson
{"title":"GABAA Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study.","authors":"Linda Steinholtz, Elin Thörnblom, Robert Bodén, Anders Wall, Hans W Axelson, Mark Lubberink, David Fällmar, Jonas Persson","doi":"10.1159/000535512","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Gamma-aminobutyric acid (GABA) deficiency is suggested in depressive disorders, along with alterations in cortical excitability. However, whether these excitability changes are related to GABAA receptor availability is largely unknown. Our aim was to assess the correlation between these measures in depressed patients and healthy controls.</p><p><strong>Methods: </strong>Twenty-eight patients with a major depressive episode, measured before and after participating in a clinical trial with repetitive transcranial magnetic stimulation (TMS), and 15 controls underwent [11C]flumazenil positron emission tomography to assess GABAA receptor availability and paired pulse TMS (ppTMS) to evaluate cortical excitability. Both whole-brain voxel-wise GABAA receptor availability and mean values from left hand motor cortex and left paracentral lobule were correlated to the ppTMS outcomes: short-interval intracortical inhibition reflecting GABAA receptor activity, long-interval intracortical inhibition representing GABAB receptor activity, intracortical facilitation reflecting glutamate N-methyl-D-aspartate-receptor activity, as well as the resting motor threshold (rMT), considered a global measure of corticospinal excitability.</p><p><strong>Results: </strong>No significant differences in baseline GABAA receptor availability or cortical excitability were found between patients and controls. Additionally, no correlations were observed between baseline measurements of GABAA receptor availability and TMS outcomes. Changes in GABAA receptor availability in the hand motor cortex, between pre- and post-assessments, were inversely related to pre-post changes in hand rMT.</p><p><strong>Conclusion: </strong>We found that a change in GABAA receptor availability was inversely related to a change in rMT, suggesting a link between GABA deficiency and increased rMT previously observed in depressive episodes. The results highlight the complex mechanisms governing cortical excitability measures and offer new insight into their properties during the depressive state.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10871686/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1159/000535512","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Gamma-aminobutyric acid (GABA) deficiency is suggested in depressive disorders, along with alterations in cortical excitability. However, whether these excitability changes are related to GABAA receptor availability is largely unknown. Our aim was to assess the correlation between these measures in depressed patients and healthy controls.

Methods: Twenty-eight patients with a major depressive episode, measured before and after participating in a clinical trial with repetitive transcranial magnetic stimulation (TMS), and 15 controls underwent [11C]flumazenil positron emission tomography to assess GABAA receptor availability and paired pulse TMS (ppTMS) to evaluate cortical excitability. Both whole-brain voxel-wise GABAA receptor availability and mean values from left hand motor cortex and left paracentral lobule were correlated to the ppTMS outcomes: short-interval intracortical inhibition reflecting GABAA receptor activity, long-interval intracortical inhibition representing GABAB receptor activity, intracortical facilitation reflecting glutamate N-methyl-D-aspartate-receptor activity, as well as the resting motor threshold (rMT), considered a global measure of corticospinal excitability.

Results: No significant differences in baseline GABAA receptor availability or cortical excitability were found between patients and controls. Additionally, no correlations were observed between baseline measurements of GABAA receptor availability and TMS outcomes. Changes in GABAA receptor availability in the hand motor cortex, between pre- and post-assessments, were inversely related to pre-post changes in hand rMT.

Conclusion: We found that a change in GABAA receptor availability was inversely related to a change in rMT, suggesting a link between GABA deficiency and increased rMT previously observed in depressive episodes. The results highlight the complex mechanisms governing cortical excitability measures and offer new insight into their properties during the depressive state.

GABAA 受体的可用性与抑郁症和健康人皮层兴奋性的关系:正电子发射断层扫描和经颅磁刺激研究》。
简介γ-氨基丁酸(GABA)缺乏被认为与抑郁症有关,同时也与大脑皮层兴奋性的改变有关。然而,这些兴奋性变化是否与 GABAA 受体的可用性有关,目前尚不清楚。我们的目的是评估抑郁症患者和健康对照组中这些指标之间的相关性:方法:28 名重度抑郁症患者在参加重复经颅磁刺激(TMS)临床试验前后接受了[11C]氟马西尼正电子发射断层扫描,以评估 GABAA 受体的可用性;15 名对照组患者接受了成对脉冲 TMS(ppTMS),以评估大脑皮层的兴奋性。全脑体素范围内的 GABAA 受体可用性以及左手运动皮层和左侧旁中心叶的平均值均与 ppTMS 的结果相关:反映GABAA受体活动的短时段皮层内抑制、代表GABAB受体活动的长时段皮层内抑制、反映谷氨酸N-甲基-D-天冬氨酸受体活动的皮层内促进以及静息运动阈值(rMT)(被认为是皮质脊髓兴奋性的总体测量指标)。研究结果在患者和对照组之间,GABAA 受体的基线可用性和皮质兴奋性没有发现明显差异。此外,GABAA 受体可用性基线测量值与 TMS 结果之间也未发现相关性。手部运动皮层 GABAA 受体可用性在评估前后的变化与手部 rMT 在评估前后的变化成反比:我们发现 GABAA 受体可用性的变化与 rMT 的变化成反比,这表明 GABA 缺乏与之前在抑郁发作中观察到的 rMT 增加之间存在联系。这些结果凸显了大脑皮层兴奋性测量的复杂机制,并为我们深入了解抑郁状态下的大脑皮层兴奋性特性提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信