Identification of TTC21A as a Potential Prognostic Marker in Head and Neck Squamous Cell Carcinoma: In Silico Analysis.

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Cancer Genomics & Proteomics Pub Date : 2024-01-01 DOI:10.21873/cgp.20428

Lili Wang, Yanping Yin, Peng Liu, Hanxiang Chen, Miao Xu

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引用次数: 0

Abstract

Background/aim: Tetratricopeptide repeat domain 21A (TTC21A) plays a crucial role in ciliary function and has been associated with various pathogenic processes, including carcinogenesis. However, its role in head and neck squamous cell carcinoma (HNSCC) has not been elucidated.

Materials and methods: Based on the sequencing and microarray data of HNSCC from publicly available databases, the expression of TTC21A was compared between different subgroups based on clinical and molecular parameters. The survival analysis and regression analysis were conducted using the Kaplan-Meier method and the Cox method, respectively. Functional analysis was performed by the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), and gene set enrichment analysis (GSEA) tools. Immune infiltration analysis was performed based on the expression of TTC21A.

Results: TTC21A decreased in tumor tissues and was associated with N stage, histologic grade, HPV infection, and TP53 mutation in HNSCC. TTC21A was an independent indicator of overall survival for patients with HNSCC. A high level of TTC21A expression indicated a favorable prognosis. The TTC21A expression level was involved with immune-related signaling regulation, immune-related gene expression, and immune cell infiltration. TTC21A expression was potent in predicting immunotherapeutic benefits.

Conclusion: TTC21A, as a potential predictor of favorable outcomes and immunotherapy response for HNSCC, is related to immune-related signaling regulation, immune-related gene expression, and immune cell infiltration.

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将 TTC21A 鉴定为头颈部鳞状细胞癌的潜在预后标记物：硅分析。

背景/目的：四肽重复结构域21A（TTC21A）在睫状肌功能中发挥着关键作用，并与包括癌变在内的多种致病过程有关。然而，它在头颈部鳞状细胞癌（HNSCC）中的作用尚未阐明：基于公开数据库中的 HNSCC 测序和芯片数据，根据临床和分子参数比较了不同亚组中 TTC21A 的表达情况。分别采用 Kaplan-Meier 法和 Cox 法进行生存分析和回归分析。功能分析采用京都基因组百科全书（KEGG）、基因本体（GO）和基因组富集分析（GSEA）工具进行。根据TTC21A的表达进行了免疫浸润分析：结果：TTC21A在肿瘤组织中减少，与HNSCC的N分期、组织学分级、HPV感染和TP53突变相关。TTC21A是HNSCC患者总生存率的独立指标。高水平的TTC21A表达预示着良好的预后。TTC21A表达水平与免疫相关信号调节、免疫相关基因表达和免疫细胞浸润有关。TTC21A的表达能有效预测免疫治疗效果：结论：TTC21A是预测HNSCC良好预后和免疫治疗反应的潜在指标，与免疫相关信号调节、免疫相关基因表达和免疫细胞浸润有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY

CiteScore

5.00

自引率

8.00%

发文量

期刊介绍： Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.