[Metabolic mechanism and intervention strategy of atrial fibrillation in the elderly].

Q3 Medicine

生理学报 Pub Date : 2023-12-25

Yuan-Qing Yang, Ling-Yan Jin, Zi-Wei Chen, Qiang-Sun Zheng, Xing-Hua Qin

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引用次数: 0

Abstract

Atrial fibrillation (AF) is a cardiovascular epidemic that occurs primarily in the elderly with primary cardiovascular diseases, leading to severe consequences such as stroke and heart failure. The heart is an energy-consuming organ, which requires a high degree of metabolic flexibility to ensure a quick switch of metabolic substrates to meet its energy needs in response to physiological and pathological stimulation. Metabolism is closely related to the occurrence of AF, and AF patients manifest metabolic inflexibility, such as insulin resistance and the metabolic shift from aerobic metabolism to anaerobic glycolysis. Moreover, our research group and the others have shown that metabolic inflexibility is a crucial pathologic mechanism for AF. Energy metabolism is closely linked to the aging process and aging-related diseases, and impaired metabolic flexibility is considered as an essential driver of aging. Therefore, this review focuses on the alteration of metabolic flexibility in the elderly and reveals that impaired metabolic flexibility may be an important driver for the high prevalence of AF in the elderly, hoping to provide intervention strategies for the prevention and treatment of AF in the elderly.

本刊更多论文

[老年人心房颤动的代谢机制和干预策略]。

心房颤动（房颤）是一种心血管流行病，主要发生在患有原发性心血管疾病的老年人身上，会导致中风和心力衰竭等严重后果。心脏是一个能量消耗器官，需要高度的代谢灵活性，以确保在生理和病理刺激下快速转换代谢底物，满足能量需求。代谢与心房颤动的发生密切相关，心房颤动患者表现出代谢不灵活，如胰岛素抵抗、代谢从有氧代谢转向无氧糖酵解等。此外，我们的研究小组和其他研究小组已经证明，代谢不灵活是心房颤动的重要病理机制。能量代谢与衰老过程和衰老相关疾病密切相关，而代谢灵活性受损被认为是衰老的重要驱动因素。因此，本综述重点关注老年人代谢灵活性的改变，揭示代谢灵活性受损可能是老年人房颤高发的重要驱动因素，希望能为预防和治疗老年人房颤提供干预策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.