Inside Front Cover: Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor (EXP2 6/2023)
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Abstract
Zhou et al. have developed pH-responsive polyserotonin-modified Salmonella carrying a self-activated DNAzyme. This novel platform minimizes immune clearance, selectively disassembling in the tumor's acidic microenvironment to reactivate Salmonella and release DNAzyme. This “Trojan horse” strategy improves therapeutic outcomes.
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