Discovery of antifungal secondary metabolites from an intestinal fungus Fusarium sp.

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2023-12-26 DOI:10.1038/s41429-023-00692-1

Mingkai Zhang, Baosong Chen, Huanqin Dai, Jingzu Sun, Hongwei Liu, Junjie Han

引用次数: 0

Abstract

Intestinal fungi, which are important parts of the gut microbiota, have the ability to produce specialized metabolites that significantly contribute to maintaining the balance of the gut microbiota and promoting the health of the host organism. In the present study, two new glycosides, including fusintespyrone A (1) and cerevisterolside A (4), as well as ten known compounds were isolated from the intestinal fungus Fusarium sp. LE06. The structures of the new compounds were elucidated by a combination of spectroscopic methods, such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), along with chemical reactions and calculations of NMR and ECD spectra. Compounds 1–3 showed significant growth inhibition against Aspergillus fumigatus, Fusarium oxysporum, and Verticillium dahliae with MIC values in the range of 1.56–6.25 μg ml−1.

Abstract Image

查看原文本刊更多论文

从肠道真菌镰刀菌中发现抗真菌次生代谢物

肠道真菌是肠道微生物群的重要组成部分，能够产生特殊的代谢产物，对维持肠道微生物群的平衡和促进宿主机体的健康有重要贡献。本研究从肠道真菌 Fusarium sp. LE06 中分离出了两种新的苷类化合物，包括 fusintespyrone A (1) 和 cerevisterolside A (4)，以及 10 种已知化合物。这些新化合物的结构是通过质谱（MS）和核磁共振（NMR）等光谱方法以及化学反应和 NMR 与 ECD 光谱计算结合起来阐明的。化合物 1-3 对烟曲霉、镰刀菌和大丽轮枝菌有明显的生长抑制作用，MIC 值在 1.56-6.25 μg ml-1 之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.