Body composition and resting energy expenditure in a group of children with achondroplasia

IF 1.3 4区医学 Q3 PEDIATRICS

Archives De Pediatrie Pub Date : 2024-02-01 DOI:10.1016/j.arcped.2023.10.005

Laura Garde-Etayo , Paula Camelia Trandafir , Céline Saint-Laurent , María Dolores Ugarte , Ana María Insausti Serrano

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引用次数: 0

Abstract

Background

Persons with achondroplasia develop early obesity, which is a comorbidity associated with other complications. Currently, there are no validated specific predictive equations to estimate resting energy expenditure in achondroplasia.

Methods

We analyzed the influence of body composition on this parameter and determined whether predictive models used for children with standard height are adjusted to achondroplasia. In this cross-sectional study, we measured anthropometric parameters in children with achondroplasia. Fat mass was obtained using the Slaughter skinfold-thickness equation and resting energy expenditure was determined with a Fitmate-Cosmed calorimeter and with predictive models validated for children with average height (Schofield, Institute of Medicine, and Tverskaya).

Results

All of the equations yielded a lower mean value than resting energy expenditure with indirect calorimetry (1256±200 kcal/day [mean±SD]) but the closest was the Tverskaya equation (1017 ± 64 kcal/day), although the difference remained statistically significant. We conclude that weight and height have the greatest influence on resting energy expenditure.

Conclusion

We recommend studying the relationship between body composition and energy expenditure in achondroplasia in more depth. In the absence of valid predictive models suitable for clinical use to estimate body composition and resting energy expenditure in achondroplasia, it is recommended to use the gold standard methods by taking into account certain anthropometric parameters.

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一组软骨发育不全儿童的身体成分和静息能量消耗：预测模型在治疗肥胖症中的效果

背景软骨发育不全患者会出现早期肥胖，这是一种与其他并发症相关的合并症。方法我们分析了身体成分对这一参数的影响，并确定用于标准身高儿童的预测模型是否适用于软骨发育不全。在这项横断面研究中，我们测量了软骨发育不全儿童的人体测量参数。脂肪量采用 Slaughter 皮褶厚度方程计算，静息能量消耗采用 Fitmate-Cosmed 热量计和针对平均身高儿童（Schofield、Institute of Medicine 和 Tverskaya）验证的预测模型测定。结果所有方程得出的平均值都低于间接热量计得出的静息能量消耗（1256±200 千卡/天[平均值±SD]），但最接近的是 Tverskaya 方程（1017±64 千卡/天），尽管两者之间的差异仍有统计学意义。我们的结论是，体重和身高对静息能量消耗的影响最大。由于缺乏适合临床使用的有效预测模型来估算软骨发育不全患者的身体成分和静息能量消耗，因此建议使用金标准方法，将某些人体测量参数考虑在内。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives De Pediatrie 医学-小儿科

CiteScore

2.80

自引率

5.60%

发文量

106

审稿时长

24.1 weeks

期刊介绍： Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.