Imipenem/cilastatin-induced acute eosinophilic pneumonia: A case report

IF 0.4 Q4 CRITICAL CARE MEDICINE

Journal of Acute Disease Pub Date : 2023-12-01 DOI:10.4103/2221-6189.390390

Gautam Jesrani, Samiksha Gupta, A. Lamba, S. Arora, Monica Gupta

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引用次数: 0

Abstract

Acute eosinophilic pneumonia (AEP) is an acute pulmonary illness caused by eosinophilic infiltration of the lung parenchyma. It can happen after using drugs such as daptomycin and minocycline. AEP induced by imipenem/cilastatin is a rare condition. A 45-year-old male patient, who previously suffered from a urinary tract infection and treated with imipenem/cilastatin antibiotic, was presented to us with acute respiratory distress, soon after the initiation of the antibiotic. Computed tomography identified pulmonary infiltrates in the upper and middle lung fields and eosinophils were found to account for 36% of differential count of the broncho-alveolar lavage fluid. He also developed peripheral eosinophilia as the disease progressed. AEP, secondary to imipenem/cilastatin therapy. Steroid therapy was administered and imipenem/cilastatin antibiotic was discontinued. The patient improved completely following the therapy and had clear lung fields on follow-up. Imipenem/cilastatin is an uncommon cause of AEP and requires close monitoring during therapy.

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亚胺培南/西司他丁诱发的急性嗜酸性粒细胞肺炎：病例报告

急性嗜酸性粒细胞肺炎（AEP）是一种由嗜酸性粒细胞浸润肺实质引起的急性肺部疾病。使用达托霉素和米诺环素等药物后也可能发生。亚胺培南/西司他丁诱发的 AEP 是一种罕见病。一名 45 岁的男性患者曾患有尿路感染，并接受过亚胺培南/西司他丁抗生素治疗。计算机断层扫描发现他的上肺野和中肺野出现了肺部浸润，支气管肺泡灌洗液的嗜酸性粒细胞占到差异计数的 36%。随着病情的发展，他还出现了外周嗜酸性粒细胞增多。亚胺培南/西司他丁治疗后继发 AEP。患者接受了类固醇治疗，并停用了亚胺培南/西司他丁抗生素。治疗后患者病情完全好转，随访时肺部视野清晰。亚胺培南/西司他丁是导致 AEP 的罕见病因，在治疗期间需要密切监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Acute Disease CRITICAL CARE MEDICINE-

自引率

20.00%

发文量

652

审稿时长

12 weeks

期刊介绍： The articles published mainly deal with pre-hospital and hospital emergency medicine, cardiopulmonary-cerebral resuscitation, critical cardiovascular disease, sepsis, severe infection, multiple organ failure, acute and critical diseases in different medical fields, sudden cardiac arrest, Intensive Care Unit (ICU), critical care medicine, disaster rescue medicine (earthquakes, fires, floods, mine disaster, air crash, et al.), acute trauma, acute toxicology, acute heart disease, and related topics. JAD sets up columns for special subjects in each issue.