Haorui Zhang, Yuanrui Gu, Ke Zhang, Yanxia Tu, Chenxi Ouyang
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引用次数: 0
Abstract
Aims
Growing preclinical and clinical evidence has suggested the potential method of umbilical cord mesenchymal stem cell (UCMSC) therapy for diabetic foot. Thus, the authors provided an outline of the application of UCMSCs in the treatment of diabetic foot and further summarized the roles and mechanisms of this therapy.
Data synthesis
With no time limitations, the authors searched the Web of Science, Cochrane Central Register of Controlled Trials, and PubMed (MEDLINE) databases. 14 studies were included, including 9 preclinical experiments and 5 clinical trials (3 RCTs and 2 single-arm trials).
Conclusions
The UCMSCs are of great efficacy and safety, and function mainly by reducing inflammation, regulating immunity, promoting growth factors, and enhancing the functions of vascular endothelial cells, fibroblasts, and keratinocytes. As a result, ulcer healing-related biological processes ensue, which finally lead to diabetic foot ulcer healing and clinical symptom improvement. UCMSC treatment enhances diabetic foot ulcer healing and has a safety profile. They function mainly by modulating immunity, promoting growth factor secretion, and enhancing cellular functions. More well-designed preclinical and clinical studies are needed to provide the most optimal protocol, the comprehensive molecular mechanisms, as well as to further evaluate the efficiency and safety profile of UCMSC treatment in diabetic foot patients.
目的越来越多的临床前和临床证据表明，脐带间充质干细胞（UCMSC）疗法是治疗糖尿病足的潜在方法。因此，作者概述了脐带间充质干细胞在糖尿病足治疗中的应用，并进一步总结了这种疗法的作用和机制。数据综述在没有时间限制的情况下，作者检索了 Web of Science、Cochrane Central Register of Controlled Trials 和 PubMed (MEDLINE) 数据库。结论 UCMSCs 具有很好的疗效和安全性，主要通过减轻炎症、调节免疫、促进生长因子以及增强血管内皮细胞、成纤维细胞和角质形成细胞的功能发挥作用。因此，溃疡愈合相关的生物过程随之发生，最终导致糖尿病足溃疡愈合和临床症状改善。UCMSC 治疗可促进糖尿病足溃疡愈合，且具有安全性。它们主要通过调节免疫、促进生长因子分泌和增强细胞功能发挥作用。我们需要更多精心设计的临床前和临床研究，以提供最理想的方案、全面的分子机制，并进一步评估 UCMSC 治疗糖尿病足患者的有效性和安全性。
期刊介绍：
Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis.
The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications.
Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.
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