Pregabalina preoperatoria previene las fasciculaciones y mialgias inducidas por succinilcolina: metaanálisis de ensayos aleatorizados

IF 0.9 Q3 ANESTHESIOLOGY

Revista Espanola de Anestesiologia y Reanimacion Pub Date : 2023-12-15 DOI:10.1016/j.redar.2022.12.004

P.A. Vélez , V. Lara-Erazo , A.F. Caballero-Lozada , A. Botero , G. Lozada , A.F. Velásquez , L.M. Villegas , A. Zorrilla-Vaca

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引用次数: 0

Abstract

Succinylcholine is the gold standard neuromuscular blocker for rapid sequence induction, however, its use is associated with fasciculations and myalgias. A systematic review and meta-analysis including randomized controlled clinical trials was performed comparing gabapentinoids versus placebo for the prevention of fasciculations and succinylcholine-induced myalgias. Six randomized clinical studies were included. The total number of patients was 481, of which 241 were in the intervention group and 240 in the placebo group. Gabapentinoids reduced the incidence of succinylcholine-induced myalgia (RR = .69; 95% CI: .56-.84; P < .001), which remained statistically significant for pregabalin (RR = .71; 95% CI: .54-.93; P = .013) and gabapentin (RR = .61; 95% CI: .45-.82; P = .001) separately. There was no difference between the groups in fasciculations (RR = .92; 95% CI: .82-1.03; P = .148). Preoperative use of gabapentinoids is associated with lower incidence of succinylcholine-induced myalgias within the first 24 hours after the procedure.

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术前使用普瑞巴林可预防琥珀酰胆碱引起的筋束收缩和肌痛：随机试验的荟萃分析

琥珀胆碱是用于快速序列诱导的金标准神经肌肉阻滞剂，但其使用与筋束收缩和肌痛有关。一项包括随机对照临床试验在内的系统综述和荟萃分析比较了加巴喷丁类药物和安慰剂在预防筋束收缩和琥珀胆碱诱发肌痛方面的效果。其中包括六项随机临床研究。患者总数为 481 人，其中干预组 241 人，安慰剂组 240 人。加巴喷丁类药物降低了琥珀胆碱诱发肌痛的发生率（RR = .69；95% CI：.56-.84；P <；.001），普瑞巴林（RR = .71；95% CI：.54-.93；P = .013）和加巴喷丁（RR = .61；95% CI：.45-.82；P = .001）分别降低了肌痛的发生率。两组之间在筋膜痉挛方面没有差异（RR = .92；95% CI：.82-1.03；P = .148）。术前使用加巴喷丁类药物可降低术后 24 小时内琥珀胆碱诱发肌痛的发生率。

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来源期刊

Revista Espanola de Anestesiologia y Reanimacion ANESTHESIOLOGY-

CiteScore

1.80

自引率

15.40%

发文量

113

审稿时长

82 days