A rare case of cerebral phaeohyphomycosis caused by Fonsecaea species in a renal transplant patient

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2023-12-14 DOI:10.1016/j.mmcr.2023.100621

Hammad Ul Haq Qureshi , Muhammad Absar , Wafa Nasser , Mohamed Tahar Yacoubi

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Abstract

Cerebral phaeohyphomycosis (CP) is a serious form of phaeohyphomycosis. We report a case of CP caused by Fonsecaea species in a 66-year-old immunocompromised renal transplant recipient female. Craniotomy was performed on an irregularly enhancing right cerebellar hemisphere lesion and abscess and tissue samples collected for microbiological and histological evaluation, showing fungal elements and Fonsecaea species was isolated. Antifungal treatment with voriconazole & liposomal amphotericin B was initiated with a temporary improvement in the patient's condition. Deep vein thrombosis jeopardized patient's prognosis. Despite aggressive surgical and medical intervention, our patient succumbed to the disease. Historically, CP has been linked with fatality rates as high as 65 %, despite surgical intervention and systemic antifungal medication.

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肾移植患者中一例罕见的由丰塞卡菌引起的脑膜真菌病

脑拟真菌病（CP）是拟真菌病的一种严重形式。我们报告了一例由丰塞卡菌引起的 CP 病例，患者是一名 66 岁的免疫功能低下的女性肾移植受者。我们对不规则强化的右侧小脑半球病灶进行了开颅手术，并采集脓肿和组织样本进行微生物学和组织学评估，结果显示有真菌成分，并分离出丰塞卡菌。开始使用伏立康唑和ampamp；两性霉素 B 脂质体进行抗真菌治疗，患者的病情暂时有所好转。深静脉血栓危及患者的预后。尽管采取了积极的手术和药物干预措施，但患者还是因病去世。从历史上看，尽管采取了手术干预和全身抗真菌药物治疗，CP 的致死率仍高达 65%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

47 days