Ulcerative colitis with autoimmune thyroid disease results in bilateral auricular ossificans:a case

IF 4.7 Q2 IMMUNOLOGY
Jiaqi Zhao , Fangxiao Liu , Lingshuo Bai , Zheng Jiao , Zihui Meng , Bo Jia , Yu Huang , Lin Liu
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Abstract

Background

Patients with ulcerative colitis (UC) often exhibit susceptibilities to multiple autoimmune diseases such as Sjogren's syndrome, primary sclerosing cholangitis, systemic lupus erythematosus, and insulin-dependent diabetes mellitus. This propensity likely stems from common pathogenic mechanisms underlying immune-mediated conditions. This report highlights the occurrence of autoimmune thyroid disease during UC exacerbations. Notably, the patient displayed petrified auricles.

Case Summary.

A 57-year-old male complained of sustained abdominal pain, diarrhea, hematochezia, and mucus for a duration of 20 days. The diagnosis of UC was confirmed via colonoscopy, histopathological examination, and small bowel MRE. Clinical evaluations revealed bilateral ectopic ossification in his ears, which appeared to develop over an unspecified timeframe. Imaging and histological evaluations substantiated the ectopic ossification diagnosis while eliminating the possibility of adrenal insufficiency. The presented case offers a unique instance of bilateral auricular ossification, which is hypothesized to result from hyperthyroidism.

Conclusion

Our case report underscores the necessity of enhancing awareness of the rare complications associated with UC. Medical practitioners should recognize the potential overlap of autoimmune thyroid disorders in UC patients. It is imperative to test for thyroid-related antibodies in such individuals, irrespective of overt thyroid dysfunction.

溃疡性结肠炎合并自身免疫性甲状腺疾病导致双侧耳廓骨化:一例
背景溃疡性结肠炎(UC)患者通常易患多种自身免疫性疾病,如斯尤格林综合征、原发性硬化性胆管炎、系统性红斑狼疮和胰岛素依赖型糖尿病。这种倾向可能源于免疫介导疾病的共同致病机制。本报告强调了自身免疫性甲状腺疾病在 UC 恶化期间的发生。病例摘要:一名 57 岁的男性主诉持续腹痛、腹泻、便血和粘液,病程长达 20 天。通过结肠镜检查、组织病理学检查和小肠 MRE,确诊为 UC。临床评估显示,他的双耳异位骨化,似乎是在不明时间段内形成的。影像学和组织学评估证实了异位骨化的诊断,同时排除了肾上腺功能不全的可能性。本病例是一个独特的双侧耳骨化病例,据推测可能是甲状腺功能亢进所致。医务工作者应认识到自身免疫性甲状腺疾病在 UC 患者中的潜在重叠性。无论是否存在明显的甲状腺功能障碍,都必须对此类患者进行甲状腺相关抗体检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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