Therapeutic drug monitoring of glycopeptide antimicrobials: An overview of liquid chromatography-tandem mass spectrometry methods

IF 3.1 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Mass Spectrometry and Advances in the Clinical Lab Pub Date : 2024-01-01 DOI:10.1016/j.jmsacl.2023.12.003

Alessia Cafaro , Sebastiano Barco , Federica Pigliasco , Chiara Russo , Marcello Mariani , Alessio Mesini , Carolina Saffioti , Elio Castagnola , Giuliana Cangemi

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Abstract

Therapeutic drug monitoring (TDM) is a critical clinical tool used to optimize the safety and effectiveness of drugs by measuring their concentration in biological fluids. These fluids are primarily plasma or blood. TDM, together with real-time dosage adjustment, contributes highly to the successful management of glycopeptide antimicrobial therapies. Understanding pharmacokinetic/pharmacodynamic (PK/PD) properties is vital for optimizing antimicrobial therapies, as the efficacy of these therapies depends on both the exposure of the patient to the drug (PK) and pharmacodynamic (PD) parameters such as the in vitro estimated minimum drug concentration that inhibits bacterial growth (MIC). Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is widely recognized as the gold standard for measuring small molecules, such as antibiotics. This review provides a comprehensive overview of LC-MS/MS methods available for TDM of glycopeptide antibiotics, including vancomycin, teicoplanin, dalbavancin, oritavancin, and telavancin.

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糖肽类抗菌药的治疗药物监测：液相色谱-串联质谱法概述

治疗药物监测（TDM）是一种重要的临床工具，通过测量生物液体中的药物浓度来优化药物的安全性和有效性。这些体液主要是血浆或血液。TDM 与实时剂量调整一起，为糖肽抗菌疗法的成功管理做出了巨大贡献。了解药代动力学/药效学（PK/PD）特性对优化抗菌疗法至关重要，因为这些疗法的疗效取决于患者对药物的暴露（PK）和药效学（PD）参数，如体外估计的抑制细菌生长的最小药物浓度（MIC）。液相色谱-串联质谱法（LC-MS/MS）被公认为测量抗生素等小分子药物的黄金标准。本综述全面概述了可用于糖肽类抗生素 TDM 的 LC-MS/MS 方法，包括万古霉素、替考拉宁、达巴万星、奥利他万星和泰拉万星。

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来源期刊

Journal of Mass Spectrometry and Advances in the Clinical Lab Health Professions-Medical Laboratory Technology

CiteScore

4.30

自引率

18.20%

发文量

审稿时长

81 days