Lack of association between IGF2BP2 genes (rs4402960 and rs11705701) polymorphism and type two diabetes mellitus.

Abstract

Background: The most frequent illness in the world is chronic disease. Diabetes type 2 is mostly caused by autoimmune disease, -cell dysfunction, and obesity. IGF2BP2 is one of the genes related to T2DM identified through GWAS (Genome-Wide Association Studies), and it has been confirmed in a range of ethnic groups.Material and methods : The samples were collected from AL Sadder Hospital's core medical city in Najaf. rs 4402960 and 11705701 of IGF2BP2 Allele-specific polymerase chain reaction T-ARMS-PCR was utilized to measure polymorphism in patients and controls (case_ control study). The statistical analysis was carried out using SPSS software.Results : There is no difference between patients and control subjects in the genotyping of (rs4402960) in the IGF2BP2 gene (p>0.05), and there is no difference between patients and control in the genotyping of (rs11705701) in the IGF2BP2 gene (p>0.05).Conclusion : Our results showed no association between The IGF2BP2 gene Polymorphisms (rs4402960 G/T and rs11705701 G/A) and T2DM patients.