Diagnosis, combined treatment, and long-term follow-up of a thymoma patient

Q4 Medicine

Pulmonologiya Pub Date : 2023-12-13 DOI:10.18093/0869-0189-2023-33-6-832-840

N. Chichkova, E. A. Kogan, V. V. Fomin, V. D. Parshin, E. Fominykh, Yu. M. Bychkov, N. V. Morozova, A. B. Ponomarev

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引用次数: 0

Abstract

Thymic neoplasms account for 20 – 25% of primary mediastinal tumors. Nonspecific clinical symptoms are often associated with delayed diagnosis of thymoma, leading to a distinctive problem of late diagnosis. Nowadays, surgical removal of the tumor is the method of choice for thymoma treatment. Combination treatment is indicated in the case of an unresectable tumor. Modern therapy (various combinations of anticancer drugs) helps reduce neoplasm size, stop metastasis, and maintain good quality of life in patients with thymoma.Aim. The presented clinical case of type B3 thymoma (with invasion into surrounding organs and metastatic pleura) is characterized by a long asymptomatic period of the disease, the onset of symptoms after suffering COVID-19 (COronaVIrus Disease 2019) and successful long-term polychemotherapy. The causes of late diagnosis, as well as insufficient oncologic vigilance in evaluating the results of laboratory and instrumental tests, are discussed based on this clinical case.Conclusion. A correct diagnosis, as well as successful treatment, requires a multidisciplinary approach involving physicians from different specialties – general practitioners, oncologists, surgeons, radiologists, and morphologists.

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一名胸腺瘤患者的诊断、综合治疗和长期随访

胸腺瘤占原发性纵隔肿瘤的 20-25% 。非特异性临床症状往往与胸腺瘤的延迟诊断有关，从而导致明显的晚期诊断问题。目前，手术切除肿瘤是治疗胸腺瘤的首选方法。联合治疗适用于无法切除的肿瘤。现代疗法（各种抗癌药物组合）有助于缩小肿瘤体积、阻止转移并保持胸腺瘤患者良好的生活质量。本临床病例为 B3 型胸腺瘤（侵犯周围器官和转移性胸膜），其特点是疾病无症状期长，在罹患 COVID-19 （COronaVIrus Disease 2019）后才出现症状，并成功接受了长期多化疗。根据该临床病例，讨论了诊断过晚的原因，以及肿瘤学家在评估实验室和仪器检测结果时警惕性不足的问题。正确的诊断和成功的治疗需要来自不同专业的医生--全科医生、肿瘤科医生、外科医生、放射科医生和形态科医生--共同参与的多学科方法。

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来源期刊

Pulmonologiya Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The aim of this journal is to state a scientific position of the Russian Respiratory Society (RRS) on diagnosis and treatment of respiratory diseases based on recent evidence-based clinical trial publications and international consensuses. The most important tasks of the journal are: -improvement proficiency qualifications of respiratory specialists; -education in pulmonology; -prompt publication of original studies on diagnosis and treatment of respiratory diseases; -sharing clinical experience and information about pulmonology service organization in different regions of Russia; -information on current protocols, standards and recommendations of international respiratory societies; -discussion and consequent publication Russian consensus documents and announcement of RRS activities; -publication and comments of regulatory documents of Russian Ministry of Health; -historical review of Russian pulmonology development. The scientific concept of the journal includes publication of current evidence-based studies on respiratory medicine and their discussion with the participation of Russian and foreign experts and development of national consensus documents on respiratory medicine. Russian and foreign respiratory specialists including pneumologists, TB specialists, thoracic surgeons, allergists, clinical immunologists, pediatricians, oncologists, physiologists, and therapeutists are invited to publish article in the journal.