The role of complement component C1q in angiogenesis

Mariagiulia Spazzapan, Silvia Pegoraro, C. Agostinis, R. Bulla
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Abstract

The complement component C1q plays a role as a pro-angiogenic factor in different contexts, acting in a complement-independent way. For example, this molecule is able to foster the remodeling of the spiral arteries for a physiological pregnancy and to promote the wound healing process. It is also involved in angiogenesis after post-stroke ischemia. Furthermore, it has a role in supporting the tumor vessel growth. Given its role in promoting angiogenesis both under physiological and pathological situations, other studies are needed to understand its potential therapeutic implications.
补体成分 C1q 在血管生成中的作用
补体成分 C1q 在不同情况下发挥着促进血管生成因子的作用,其作用方式与补体无关。例如,这种分子能够促进螺旋动脉的重塑,以利于生理妊娠,并促进伤口愈合过程。它还参与中风后缺血的血管生成。此外,它还在支持肿瘤血管生长方面发挥作用。鉴于它在生理和病理情况下促进血管生成的作用,还需要其他研究来了解其潜在的治疗意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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