Intraflagellar transport: A critical player in photoreceptor development and the pathogenesis of retinal degenerative diseases

IF 2.4 4区生物学 Q4 CELL BIOLOGY

Cytoskeleton Pub Date : 2023-12-23 DOI:10.1002/cm.21823

Mohona Gupta, Gregory J. Pazour

引用次数: 0

Abstract

In vertebrate vision, photons are detected by highly specialized sensory cilia called outer segments. Photoreceptor outer segments form by remodeling the membrane of a primary cilium into a stack of flattened disks. Intraflagellar transport (IFT) is critical to the formation of most types of eukaryotic cilia including the outer segments. This review covers the state of knowledge of the role of IFT in the formation and maintenance of outer segments and the human diseases that result from mutations in genes encoding the IFT complex and associated motors.

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囊内转运：感光器发育和视网膜变性疾病发病机制中的关键角色。

在脊椎动物的视觉中，光子是由被称为外节的高度特化的感觉纤毛探测到的。感光器外节是通过将初级纤毛的膜重塑为一叠扁平的圆盘而形成的。纤毛内运输（IFT）对于包括外节在内的大多数真核生物纤毛的形成至关重要。本综述介绍了 IFT 在外层纤毛的形成和维持过程中的作用，以及编码 IFT 复合物和相关马达的基因突变导致的人类疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytoskeleton CELL BIOLOGY-

CiteScore

5.50

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Cytoskeleton focuses on all aspects of cytoskeletal research in healthy and diseased states, spanning genetic and cell biological observations, biochemical, biophysical and structural studies, mathematical modeling and theory. This includes, but is certainly not limited to, classic polymer systems of eukaryotic cells and their structural sites of attachment on membranes and organelles, as well as the bacterial cytoskeleton, the nucleoskeleton, and uncoventional polymer systems with structural/organizational roles. Cytoskeleton is published in 12 issues annually, and special issues will be dedicated to especially-active or newly-emerging areas of cytoskeletal research.