Laryngeal graft after total laryngectomy in humans: A SWiM analysis

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-01 DOI:10.1016/j.anorl.2023.12.001

P. Céruse , S. Vergez , J.-P. Marie , B. Baujat , F. Jegoux , O. Malard , S. Albert , L. Badet , J. Blanc , S. Deneuve , F. Faure , C. Fuchsmann , E. Morelon , P. Philouze , ECLAT group

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引用次数: 0

Abstract

Evaluation of the results of laryngeal transplantation (LT) in humans. Analysis of 3 bibliographic databases with the keywords “larynx, transplantation, autograft”. In total, 626 abstracts were read and 25 articles selected. The main objective was to analyze the characteristics of laryngeal transplant patients. The accessory objectives comprised analysis of operative technique, immunosuppressive treatment and results. Four articles were selected for analysis. Two patients were transplanted after total laryngectomy for laryngeal carcinoma and 2 after laryngeal trauma. Three of the 4 patients had true transplantation with arterial, venous and neural microanastomosis. Two patients were decannulated and the tracheostomy tube was maintained in the other 2. Three of the 4 patients had good-quality phonation and could feed without a gastric tube. One patient died of carcinoma progression and 1 patient had to be explanted 14 years after transplantation. The number of LTs reported is too small for scientific determination of the place of this intervention in laryngology. The published results could, at first sight, suggest that the future of LT is uncertain. However, several elements, also suggest that otolaryngologists should continue to take an interest in this technique.

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人类全喉切除术后的喉移植：SWiM 分析。

评估人类喉移植（LT）的结果。以 "喉、移植、自体移植 "为关键词对 3 个文献数据库进行分析。共阅读了 626 篇摘要，筛选出 25 篇文章。主要目的是分析喉移植患者的特征。辅助目标包括分析手术技术、免疫抑制治疗和结果。共选取了四篇文章进行分析。其中两名患者是在喉癌全喉切除术后进行的移植，两名是在喉创伤后进行的移植。4 名患者中有 3 名进行了真正的移植，并进行了动脉、静脉和神经微吻合术。其中两名患者进行了气管切开术，另外两名患者保留了气管造口管。4 名患者中有 3 人发音质量良好，无需胃管即可进食。一名患者死于癌变，一名患者在移植 14 年后不得不进行切除手术。报告的LT数量太少，无法科学地确定这种干预在喉科中的地位。乍看之下，已发表的结果可能表明，LT 的前景并不明朗。然而，一些因素也表明，耳鼻喉科医生应继续关注这项技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.