Males and females with scleroderma: A comparative study in a Brazilian sample.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-18 eCollection Date: 2023-12-01 DOI:10.46497/ArchRheumatol.2023.10011

Matheus Costa, Igor Jorge, Patricia Martin, Renato Nisihara, Thelma Skare

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引用次数: 0

Abstract

Objectives: This study aimed to evaluate the clinical and serological profile in systemic sclerosis (SSc) by comparing females and males.

Patients and methods: This retrospective study was conducted with 215 SSc patients (193 females, 22 males; mean age: 50.1±14.5 years; range, 16 to 88 years) between September 2005 and September 2020. Disease severity was calculated by the Medsger severity score. Males and females were compared for clinical and serological markers.

Results: Females more frequently had esophageal involvement (p=0.003), telangiectasias (p=0.03), and antinuclear antibodies (p=0.04). Males more frequently had fingertip scars (p=0.03), digital ulcers (p=0.006), and a worse median Medsger severity score (6 in males vs. 4 in females, p=0.05).

Conclusion: In the studied sample, males had more severe disease than females with greater repercussions in periferic circulatory system.

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男性和女性硬皮病患者：巴西样本比较研究。

研究目的本研究旨在通过比较女性和男性，评估系统性硬化症（SSc）的临床和血清学特征：这项回顾性研究的对象是 2005 年 9 月至 2020 年 9 月期间的 215 名 SSc 患者（女性 193 人，男性 22 人；平均年龄：50.1±14.5 岁；年龄范围：16 至 88 岁）。疾病严重程度按 Medsger 严重程度评分计算。比较了男性和女性的临床和血清学指标：结果：女性更常见食管受累（p=0.003）、毛细血管扩张（p=0.03）和抗核抗体（p=0.04）。男性更常出现指尖疤痕（p=0.03）、数字溃疡（p=0.006），中位数Medsger严重程度评分更差（男性6分，女性4分，p=0.05）：结论：在研究样本中，男性比女性病情更严重，对周围循环系统的影响更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.