Males and females with scleroderma: A comparative study in a Brazilian sample.

IF 1.1 Q4 RHEUMATOLOGY

Archives of rheumatology Pub Date : 2023-08-18 eCollection Date: 2023-12-01 DOI:10.46497/ArchRheumatol.2023.10011

Matheus Costa, Igor Jorge, Patricia Martin, Renato Nisihara, Thelma Skare

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Abstract

Objectives: This study aimed to evaluate the clinical and serological profile in systemic sclerosis (SSc) by comparing females and males.

Patients and methods: This retrospective study was conducted with 215 SSc patients (193 females, 22 males; mean age: 50.1±14.5 years; range, 16 to 88 years) between September 2005 and September 2020. Disease severity was calculated by the Medsger severity score. Males and females were compared for clinical and serological markers.

Results: Females more frequently had esophageal involvement (p=0.003), telangiectasias (p=0.03), and antinuclear antibodies (p=0.04). Males more frequently had fingertip scars (p=0.03), digital ulcers (p=0.006), and a worse median Medsger severity score (6 in males vs. 4 in females, p=0.05).

Conclusion: In the studied sample, males had more severe disease than females with greater repercussions in periferic circulatory system.

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男性和女性硬皮病患者：巴西样本比较研究。

研究目的本研究旨在通过比较女性和男性，评估系统性硬化症（SSc）的临床和血清学特征：这项回顾性研究的对象是 2005 年 9 月至 2020 年 9 月期间的 215 名 SSc 患者（女性 193 人，男性 22 人；平均年龄：50.1±14.5 岁；年龄范围：16 至 88 岁）。疾病严重程度按 Medsger 严重程度评分计算。比较了男性和女性的临床和血清学指标：结果：女性更常见食管受累（p=0.003）、毛细血管扩张（p=0.03）和抗核抗体（p=0.04）。男性更常出现指尖疤痕（p=0.03）、数字溃疡（p=0.006），中位数Medsger严重程度评分更差（男性6分，女性4分，p=0.05）：结论：在研究样本中，男性比女性病情更严重，对周围循环系统的影响更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archives of rheumatology

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