Regulation of Macrophage Polarization in Allergy by Noncoding RNAs.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-Coding RNA Pub Date : 2023-12-11 DOI:10.3390/ncrna9060075

Osamu Ishibashi, Stefan A Muljo, Zohirul Islam

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引用次数: 0

Abstract

Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such as peanuts, plant pollen, fungal spores, and the feces and debris of mites and insects. Macrophages are myeloid immune cells with phagocytic abilities that process exogenous and endogenous antigens. Upon activation, they can produce effector molecules such as cytokines as well as anti-inflammatory molecules. The dysregulation of macrophage function can lead to excessive type 1 inflammation as well as type 2 inflammation, which includes allergic reactions. Thus, it is important to better understand how macrophages are regulated in the pathogenesis of allergies. Emerging evidence highlights the role of noncoding RNAs (ncRNAs) in macrophage polarization, which in turn can modify the pathogenesis of various immune-mediated diseases, including allergies. This review summarizes the current knowledge regarding this topic and considers three classes of ncRNAs: microRNAs, long ncRNAs, and circular ncRNAs. Understanding the roles of these ncRNAs in macrophage polarization will provide new insights into the pathogenesis of allergies and identify potential novel therapeutic targets.

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非编码 RNA 对过敏症中巨噬细胞极化的调控

过敏是由称为过敏原的抗原引发的第二类免疫反应，包括食物和环境物质，如花生、植物花粉、真菌孢子以及螨虫和昆虫的粪便和碎屑。巨噬细胞是一种髓系免疫细胞，具有吞噬能力，可处理外源性和内源性抗原。巨噬细胞活化后可产生细胞因子等效应分子和抗炎分子。巨噬细胞功能失调可导致过度的 1 型炎症和包括过敏反应在内的 2 型炎症。因此，更好地了解巨噬细胞在过敏症发病机制中是如何调节的非常重要。新出现的证据强调了非编码 RNA（ncRNA）在巨噬细胞极化中的作用，而巨噬细胞极化反过来又能改变包括过敏症在内的各种免疫介导疾病的发病机制。本综述总结了目前有关这一主题的知识，并考虑了三类 ncRNA：microRNA、长 ncRNA 和环状 ncRNA。了解这些 ncRNA 在巨噬细胞极化过程中的作用将为了解过敏症的发病机制和确定潜在的新治疗靶点提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.