Evaluating the molecular and genetic mechanisms underlying gut motility disorders.

IF 3.8 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Expert Review of Gastroenterology & Hepatology Pub Date : 2023-12-01 Epub Date: 2024-01-17 DOI:10.1080/17474124.2023.2296558

Atchariya Chanpong, Maria M Alves, Elena Bonora, Roberto De Giorgio, Nikhil Thapar

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引用次数: 0

Abstract

Introduction: Gastrointestinal (GI) motility disorders comprise a wide range of different diseases affecting the structural or functional integrity of the GI neuromusculature. Their clinical presentation and burden of disease depends on the predominant location and extent of gut involvement as well as the component of the gut neuromusculature affected.

Areas covered: A comprehensive literature review was conducted using the PubMed and Medline databases to identify articles related to GI motility and functional disorders, published between 2016 and 2023. In this article, we highlight the current knowledge of molecular and genetic mechanisms underlying GI dysmotility, including disorders of gut-brain interaction, which involve both GI motor and sensory disturbance.

Expert opinion: Although the pathophysiology and molecular mechanisms underlying many such disorders remain unclear, recent advances in the assessment of intestinal tissue samples, genetic testing with the application of 'omics' technologies and the use of animal models will provide better insights into disease pathogenesis as well as opportunities to improve therapy.

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评估肠道运动紊乱的分子和遗传机制。

导言：胃肠道（GI）运动障碍包括一系列影响胃肠道神经肌肉结构或功能完整性的不同疾病。其临床表现和疾病负担取决于肠道受累的主要部位和程度，以及受影响的肠道神经肌肉的组成部分：我们使用 PubMed 和 Medline 数据库进行了全面的文献综述，以确定 2016-2023 年间发表的与肠道运动和功能性疾病相关的文章。在这篇文章中，我们重点介绍了目前有关消化道运动障碍的分子和遗传机制的知识，包括涉及消化道运动和感觉障碍的肠脑相互作用紊乱：尽管许多此类疾病的病理生理学和分子机制仍不清楚，但最近在肠道组织样本评估、应用'omics'技术进行基因检测以及使用动物模型方面取得的进展，将为我们提供更好的疾病发病机制见解以及改善治疗的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.80

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.