Challenging the concept of “risk of malignancy” in cytology

IF 2.6 3区 医学 Q3 ONCOLOGY
Ilias P. Nikas MD, Ricella Souza da Silva MD, PhD, Bernardo Sousa-Pinto MD, PhD, Fernando Schmitt MD, PhD, FIAC
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引用次数: 0

Abstract

Several standardized systems for nongynecological cytopathology have been published following the successful implementation of The Bethesda System for Reporting Cervical Cytology. Each of these systems comprises a set of reporting categories accompanied by a risk of malignancy. However, in most cases, these risk of malignancy estimates have not been based on high-quality evidence and often may not be consider proper “risks” (because they have been estimated based on cross-sectional studies). This commentary discusses the problems related to the data used to generate these risks. To make nongynecological cytopathology reporting more evidence-based, large-scale prospective cohort studies and randomized trials, in addition to high-quality systematic reviews and meta-analyses, should be performed.

挑战细胞学中的 "恶性风险 "概念。
贝塞斯达宫颈细胞学报告系统》成功实施后,又发布了多个非妇科细胞病理学标准化系统。每个系统都包含一套报告类别,并附有恶性风险。然而,在大多数情况下,这些恶性肿瘤风险估计值并非基于高质量的证据,而且通常可能并不被认为是适当的 "风险"(因为它们是基于横断面研究进行估计的)。本评论讨论了与生成这些风险所使用的数据有关的问题。为使非妇科细胞病理学报告更有依据,除高质量的系统综述和荟萃分析外,还应开展大规模的前瞻性队列研究和随机试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Cytopathology
Cancer Cytopathology 医学-病理学
CiteScore
7.00
自引率
17.60%
发文量
130
审稿时长
1 months
期刊介绍: Cancer Cytopathology provides a unique forum for interaction and dissemination of original research and educational information relevant to the practice of cytopathology and its related oncologic disciplines. The journal strives to have a positive effect on cancer prevention, early detection, diagnosis, and cure by the publication of high-quality content. The mission of Cancer Cytopathology is to present and inform readers of new applications, technological advances, cutting-edge research, novel applications of molecular techniques, and relevant review articles related to cytopathology.
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