Safety and efficacy of plasma-activated water on prolonged viral shedding of COVID-19 patients: A randomized controlled trial

IF 2.9 3区物理与天体物理 Q2 PHYSICS, APPLIED

Plasma Processes and Polymers Pub Date : 2023-12-20 DOI:10.1002/ppap.202300195

Xiaoya Guo, Xing Lv, Yunfu Wu, Mingming Wang, Shuo Wu, Li Guo, Zifeng Wang, Zhihong Shi, Rui Huang, Hua Zhang, Xiaona Niu, Mingzhe Rong, Liqiang Song, Dingxin Liu

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Abstract

Shortening the duration of the viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to controlling viral transmission, alleviating the burden on the healthcare system, and ultimately mitigating the impact of the pandemic. This randomized, single-blind, placebo-controlled clinical trial aimed to investigate the safety and efficacy of gargling with plasma-activated water (PAW) on prolonged viral shedding in patients infected with SARS-CoV-2 Delta and Omicron variants. Sixty-two subjects, aged 18–80 years and infected with SARS-CoV-2, were recruited at two coronavirus disease 2019 (COVID-19)-designated hospitals in Shaanxi from January to March 2022. Primary outcomes included cumulative conversion rates, incidence of adverse reactions, and biosafety parameters. Results suggested that PAW gargling treatment might contribute to reducing the duration of SARS-CoV-2 Delta and Omicron variant infections and alleviating symptoms.

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血浆活化水对延长 COVID-19 患者病毒脱落期的安全性和有效性：随机对照试验

缩短严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）的病毒脱落期对于控制病毒传播、减轻医疗系统的负担以及最终减轻大流行的影响至关重要。这项随机、单盲、安慰剂对照临床试验旨在研究用血浆活化水（PAW）漱口对感染 SARS-CoV-2 Delta 和 Omicron 变体的患者病毒长期脱落的安全性和有效性。2022年1月至3月，在陕西两家冠状病毒病2019（COVID-19）定点医院招募了62名SARS-CoV-2感染者，年龄在18-80岁之间。主要结果包括累计转阴率、不良反应发生率和生物安全参数。结果表明，PAW漱口治疗可能有助于缩短SARS-CoV-2 Delta和Omicron变异型感染的持续时间并减轻症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasma Processes and Polymers 物理-高分子科学

CiteScore

6.60

自引率

11.40%

发文量

150

审稿时长

3 months

期刊介绍： Plasma Processes & Polymers focuses on the interdisciplinary field of low temperature plasma science, covering both experimental and theoretical aspects of fundamental and applied research in materials science, physics, chemistry and engineering in the area of plasma sources and plasma-based treatments.