Oncology for the rhinologist.

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2024-02-01 Epub Date: 2023-12-06 DOI:10.1097/MOO.0000000000000951

Kenric Tam, Lara A Dunn, Marc A Cohen

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引用次数: 0

Abstract

Purpose of review: The purpose of this review is to summarize current evidence regarding the use of induction chemotherapy for a variety of histopathologies of sinonasal malignancy (SNMs) and to review the potential adverse effects of cytotoxic agents.

Recent findings: Historically, patients with locally advanced SNMs have had relatively poor prognoses and high morbidity from treatment. The available retrospective data suggests that induction chemotherapy may improve outcomes for patients with sinonasal undifferentiated carcinoma (SNUC), neuroendocrine carcinoma, squamous cell carcinoma (SSCC), and esthesioneuroblastoma. For SNUC and SSCC, response or nonresponse to induction chemotherapy may prognosticate outcomes and for SNUC specifically, drive selection of definitive therapy. In chemosensitive pathologies, induction chemotherapy appears to improve organ preservation.

Summary: Induction chemotherapy may improve functional and oncologic outcomes for patients with SNMs. Because of the rarity of these pathologies, the available data is primarily retrospective. Future randomized, prospective studies should be performed to further optimize and elucidate the role of induction chemotherapy for SNMs.

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鼻科医生的肿瘤学

综述目的：本综述旨在总结有关鼻窦鼻腔恶性肿瘤（SNMs）各种组织病理学诱导化疗的现有证据，并回顾细胞毒药物的潜在不良反应：从历史上看，局部晚期鼻窦恶性肿瘤患者的预后相对较差，治疗的发病率也较高。现有的回顾性数据表明，诱导化疗可改善鼻窦鼻腔未分化癌（SNUC）、神经内分泌癌、鳞状细胞癌（SSCC）和雌母细胞瘤患者的预后。对于鼻窦未分化癌（SNUC）和鳞状细胞癌（SSCC），对诱导化疗的反应或无反应可预示预后，特别是对于鼻窦未分化癌（SNUC），可推动确定性疗法的选择。总结：诱导化疗可改善SNM患者的功能和肿瘤预后。由于这些病变的罕见性，现有数据主要是回顾性的。未来应开展随机、前瞻性研究，进一步优化和阐明诱导化疗对SNM的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Otolaryngology & Head and Neck Surgery OTORHINOLARYNGOLOGY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Otolaryngology & Head and Neck Surgery is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including maxillofacial surgery, head and neck oncology and speech therapy and rehabilitation – every issue also contains annotated references detailing the merits of the most important papers.

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