2021 World Health Organization Classification of Brain Tumors.

Q1 Medicine

CONTINUUM Lifelong Learning in Neurology Pub Date : 2023-12-01 DOI:10.1212/CON.0000000000001355

David M Meredith, David J Pisapia

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引用次数: 0

Abstract

Objective: The classification of brain tumors is a rapidly evolving field that requires extensive integration of molecular diagnostic findings from an expanding set of platforms and assays. This article summarizes the schema presented in the 5th edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors while highlighting diagnostic molecular findings and discussing the strengths and weaknesses of commonly available testing modalities.

Latest developments: Several major changes in practice were introduced with the 5th edition of the CNS WHO classification, including molecular grading of adult diffuse gliomas, the introduction of many new entities within the spectrum of pediatric gliomas and glioneuronal tumors, and the widespread adoption of methylation classes as useful or even necessary diagnostic criteria. Additionally, several revisions to nomenclature (eg, IDH-mutant gliomas) were introduced for simplicity and to disambiguate from other tumor types.

Essential points: The classification of brain tumors continues to grow in complexity alongside our improved understanding of their nuanced molecular underpinnings.

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2021 年世界卫生组织脑肿瘤分类。

目的：脑肿瘤分类是一个快速发展的领域，需要广泛整合来自不断扩大的平台和检测方法的分子诊断结果。本文总结了世界卫生组织（WHO）第五版中枢神经系统（CNS）肿瘤分类的模式，同时重点介绍了分子诊断结果，并讨论了常用检测模式的优缺点：中枢神经系统 WHO 分类法第五版在实践中引入了若干重大变化，包括成人弥漫性胶质瘤的分子分级、在小儿胶质瘤和胶质细胞瘤谱系中引入许多新实体，以及广泛采用甲基化分类作为有用甚至必要的诊断标准。此外，还对命名法（如 IDH 突变胶质瘤）进行了若干修订，以简化命名并与其他肿瘤类型区分开来：要点：随着我们对脑肿瘤微妙的分子基础的理解不断加深，脑肿瘤的分类也越来越复杂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CONTINUUM Lifelong Learning in Neurology Medicine-Medicine (all)

CiteScore

5.80

自引率

0.00%

发文量

175

期刊介绍： Continue your professional development on your own schedule with Continuum: Lifelong Learning in Neurology®, the American Academy of Neurology" self-study continuing medical education publication. Six times a year you"ll learn from neurology"s experts in a convenient format for home or office. Each issue includes diagnostic and treatment outlines, clinical case studies, a topic-relevant ethics case, detailed patient management problem, and a multiple-choice self-assessment examination.